ISSN: 1991-8941

Coronavirus Current and New Potential Therapeutic Targets: A Review

Jwan O. Abdulsattar; Saad T. Mutlk; Ban O. Abdulsattar

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 1-10

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emergence in late 2019 marked the introduction of a highly spread viral pathogen threatening human population globally. The new virus is closely related genetically and clinically to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). There are no specific antiviral drugs approved against human coronavirus infection and all treatments are supportive. The genome of coronavirus contains several open reading frames (ORFs) that encode both non-structural proteins (nsp) and structural proteins. Most of the encoded proteins have been reported as multifunctional proteins and plays a specific role in coronavirus (CoV) replication and assembly. This review focuses on the potential vaccine and antiviral targets for coronavirus, including different proteins and genes. Understanding the current targets and discovering new possible therapeutic targets will help toward developing effective vaccines and antiviral drug against current SARS-CoV-2 outbreak and possible future outbreak.
 

 

An Overview: Using Different Approaches to Synthesis New Schiff Bases Materials

Anahed A. Yaseen; Emaad T. B. Al-Tikrity; Mohammed H. Al-Mashhadan; Nadia Salih; Emad Yousif

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 3-59

Schiff base compounds are called relative to the scientist who first prepared them (Hugo Schiff). They are synthesized by the condensation reaction of the carbonyl group –C=O– of the aldehyde or ketone compound with a primary amine. This leads to the formation of azomethine or imine group –C=N– plus water molecule. Schiff base molecules have gained special importance due to their biological activity, such as anti-inflammatory and antibiotic. Schiff base compounds are also utilized in the industry as corrosion inhibitors, dyes, and photo-stabilizers of plastic polymers. This short review includes highlighting of recent approaches of synthesis novel Schiff base molecules. It also discusses the mechanism of the reaction and why it is a reversible condensation reaction.
 

 

Study Of Some Anatomical Features Of Stevia Rebaudiana (Bertoni) Bertoni Grown In Iraq

Ali T. AL-Taie

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 11-14

The leaves of Stevia rebaudiana, from Asteraceae family, are a source of steviol glycosides, which are utilized as a sweeter, more favorite addition. Among the most important anatomical results that were reached through the research and which distinguish the plant from an anatomical point of view are uniseriate-multicellular of non-glandular trichomes that are covered the epidermis of stem and leaves. Also, the vertical walls of the ordinary epidermis cells in the upper and lower epidermis that are heavily sinuous and the stomata scattered in both of it, the type of the stomata anomocytic. In addition, the mesophyll which differentiated into 2-3 layers of palisade cells under the upper epidermis and the spongy cells after it and the cross-section of midrib region of the leaf as crescent shape and the vascular bundle central, crescent shape.
 

 

Effect of Two Types of Diet on Cholecystokinin (CCK) Level in Three Groups of Males

Nour Shakir Rezaieg

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 15-19

In response to a meal, the signals of satiety suppress the signals of hunger (meaning to finish the meal). These signals originate in the pancreas and gastrointestinal tract, transmitting information from the periphery to the brain (by the vagus nerve or the circulation). The study aimed to estimate whether the serum level of Cholecystokinin (CCK) in three male groups is influenced by their type of food. The current study included Sixty volunteers of adult males (normal-weight group n=20, overweight group n=20, and obese I group n=20) (21- 24 years). The blood samples were taken from subjects in the afternoon after (30 minutes–2 hours) from lunch was consumed, during March 2021 till June 2021. ELIZA kit was used to assay the serum concentration of the Cholecystokinin hormone. The anthropometric measurements were done, such as body weight and height, to calculate body mass index (BMI) by special formula, and the subjects were assorted depending on WHO body mass index (BMI) classification. Cholecystokinin showed a significant decrease (p<0.05) in obese I (311.201±21.542) and overweight (353.494 ± 43.915) as compared with the normal weight group (646.002 ± 46.344). A significant negative correlation was noticed between the hormone and body weight. Eating palatable food leads to uncontrolled ingesting behaviors due to the shift from homeostatic to hedonic regulatory mechanisms of food intake. These changes occur primarily in individuals with obesity and thus lead to an irregularity in the secretion of anorexigenic hormones.
 

 

A Short Review: Genetic Risk Factors of Stroke

Hadeel Abdelelah Abdel Razaaq

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 20-26

A stroke happens when an artery in the brain gets blocked or ruptured, which results in the death of a brain tissue area because of a loss of its blood supply (brain infarction). Most strokes are ischemic strokes caused by ischemia due to arterial occlusion, but some are hemorrhagic strokes caused by an arterial rupture. Transient ischemic attacks have been considered similar to ischemic strokes. However, they cause no permanent damages to the brain, and their signs usually resolve during 1 h., which are sometimes called mini-strokes. As for hemorrhagic strokes that cause a blood clot, that is, that deprives brain cells of blood supply, and therefore enough oxygen and glucose, the damage depends on the length of time the brain cells are deprived of blood, for example, If brain cells are deprived of the blood for only a short period of time, they can be slightly damaged, but if brain cells are deprived of blood for a longer period, the cells may die, and thus the patient loses some body functions, sometimes permanently. High blood pressure has been defined as the leading risk factor for strokes, and there are other factors like smoking, high blood cholesterol, obesity, atrial fibrillation, diabetes, and others. Strokes are more common among the elderly than younger adults because of the risks of injuries that result in causing strokes with age. Statistics have indicated that over 2/3 of the strokes happen in people who are older than 65, while the rates of strokes in men are very slightly higher than women, but more than 60% of stroke deaths occur in women, and this may be because women They have a stroke at a slightly higher (average) age than men. Black people have a higher possibility of getting a stroke than white people.
 

 

Review: Biological Bases and Characterization of Long Non-Coding RNAs

Mustafa Nuhad Al-Darraji; Harith Abdulrhman Ahmed; Thulfiqar Fawwaz Mutar

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 27-34

Long non-coding RNAs (lncRNAs) were known not so long ago as a type of diverse non-coding RNAs that have received much attention due to their multiple regulatory activities at the nuclear and cellular level and their essential participation in the regulation of many chemical and biological activities. Although lncRNAs are expressed at low levels, they do not encode proteins, are insufficiently conserved, and act by various mechanisms. However, some characteristics and functions of several copies of lncRNAs separate them from other forms of non-coding RNA have been discovered. Here we will look at how events develop in lncRNAs and talk about their main biological properties and influences, as well as how to achieve such a wide range of functions using a variety of mechanisms such as protein transfer, gene transcription, chromatin rearrangement, unique properties, and other biological activities.
 

 

Review Of Covid-19 Vaccines

Hadeel Kareem Musafer; Raghad Abdulatif Abdulrazaq; Baidaa Mijbel Ali; Sadeq Abdulridha Gatea Kaabi

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 35-44

SAR-COV2 is still a pressing issue, 219M people were infected and more than 4.5M lost their lives. The majority of antiviral and inflammatory therapies could only provide a supportive role in treating a limited number of COVID cases. This review investigates the available vaccines in terms of their safety and efficiency in fighting the virus. Seven vaccines are similar in their side effects to other influenza vaccines and their necessity to a booster dose. Although that several technologies have been used to manufacture the vaccine, mRNA vaccines clearly show a high protection rate touched 90% specially in severe and hospitalization cases prevention. Among all available vaccines, Pfizer vaccine is an exception as it granted the full approval to be used in people age 16 and under till five years.
 

 

Preparation of poly hydroxamic acid from poly (styrene –methyl metha acrylate) and study of the kinetics of nickel ion sorption by the prepared acid

Fatima Khalil Ibrahim; Saddaa Abed Abedullah

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 45-52

In this paper, the copolymer (styrene-methyl methacrylate) was prepared by using free radical polymerization for the copolymerization between methyl methacrylate and styrene in an equal molar mixing ratio and using benzoyl peroxide as a starter at a temperature of 70 °C. Then the prepared copolymer was converted to poly hydroxamic acid, and this was done by reacting the copolymer with hydroxylamine hydrochloride at a base medium of = 13 using sodium hydroxide with heat escalation for a period of 70 °C. The nickel ion sorption capacity of the resultant product was evaluated using poly hydroxamic acid and spectroscopic FT-IR. As well as studying the effect of time, temperature, and acidity function on the sorption capacity by chelating poly hydroxamic acid. Where it was shown that the capacity of adsorption increases with increasing time and decreases with increase in temperature mediated by poly hydroxamic acid. The equations of Arrhenius and Vant Hof were used, and from the enthalpy values, it was shown that the reaction was exothermic, and from the negative compression energy values, it was found that the reaction is spontaneous and the type of physical detention is mediated by poly hydroxamic acid.
 

 

Novel Ester Monomers and Its Transition Metal Polychelates and Their Photovoltaic Application On Dye Sensitized Solar Cells

Sadeem M Al-Barody

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 60-65

A novel ligand N-(2-hydroxyl phenyl)-(4-pentloxy-benzate-salicyIidene) (H2L) prepared by 1:1 molar ratio of 4-pentyloxy (4-formyl-3-hydroxy)-benzoate and 2-aminophenol, synthesis of [M(H2L)H2O] and [Cu2L2] complexes were described by IR spectroscopy, C.H.N.O, 1H, 13CNMR, , GCmass. photovoltaic measurement of H2L and Cu2L2 as photosensitizers by dye-sensitized solar cells (DSSCs) the best result was for Cu2L2 than H2L.
 

 

A Review On Organotin(Iv) Thiosemicarbazone Complexes, Synthesis, Characterization And Biological Activity

Rawnaq B. Jimaa; Jinan Mohammed Mahmood Al-Zinkee

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 66-73

Organotin(IV) complexes recently have been receiving great attention due to their stability with a unique structure, physical and chemical properties. There are many applications, the organotin(IV) can be used as catalysts, antifouling agents, UV- and heat stabilizers, anticorrosion, anticancer and antimicrobial activities. This review summarizes the synthesis methods, characterization and biological activities of organotin(IV) thiosemicarbazones derivatives with their activities as anticancer and antimicrobial agents.
 

 

Synthesis and Characterization of Spinel Ferrite Co0.8Fe2.2O4 Nanoparticle

Mohammed B. Jumaa; Tahseen H Mubaraka; Ali. M. Mohammad

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 74-82

Cobalt ferrite Co0.8Fe2.2O4 nanoparticles were prepared using the sol-gel auto combustion process. The effects of calcination temperature on structural, magnetic, and electrical properties were studied. The cubic spinel phase fashioning of ferrite structure was confirmed using Fourier Transform-Infrared Spectroscopy (FT-IR) and X-ray Diffraction Patterns (XRD). The size of the formed crystallite of ferrite samples is ranged from 24.530 to 49.067 nm and it is found to be dependent on calcination. According to the images, which were taken by a Field Emission-Scanning Electron Microscope (FE-SEM), the particle size increases with raising the calcination temperature. Energy Dispersive Spectrum (EDS) was used to confirm the presence of Co, Fe, and O in all samples. A Vibrating Sample Magnetometer (VSM) was used to study the magnetic properties such as coercivity, saturation magnetization, and remanence field for the as-burnt and calcined samples. All samples exhibited ferrimagnetic behavior. As the calcination temperature rises, saturation magnetization (M_s), remanent magnetization (M_r), and squareness ratio (M_r/ M_s) increased. This behavior is related to the spin canting and disturbance in the surface spin. At room temperature, the dielectric loss factor (ε''), dielectric loss angle (tanδ), dielectric constant (ε'), and the conductivity σ_ac of all samples were examined as a function of frequency using the LCR meter. The changes in dielectric properties have been characterized at frequencies ranged from 50Hz to 2MHz based on Koop's theory, Maxwell-Wagner polarization, and electron hopping. As frequency rose, all-dielectric properties exhibited natural behavior.
 

 

The Measurement of Radionuclides Level in Different Iraqi Building Material Samples from Baghdad City

Tahseen H Mubaraka; S.S. Farhan; Mirvat Dawood Majeed; Basim Khalaf Rejah; Dawser H. Ghayb; Hamid H. Murbat

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 83-86

Measurement of naturally and artificial radionuclide concentrations deposited in Iraqi building materials used in housing construction in the Baghdad city. Six samples from different sites have chosen. (Soil, Gipson, Cement, Brick, Sand, Gravel). The high purity Germanium detector (HpGe) have been used to measure the concentration of gamma emitter radionuclides from both uranium – radium and thorium series, 40K and 137Cs. The spectra for each sample were analyzed for (7200 sec). The percentage errors were calculated. The range of specific activities for studied radionuclides were as follows: The average concentrations of 238U is between (13-70) Bq/kg, 232Th is (2-34) Bq/kg, 40K is (39-880) Bq/kg, and 137Cs is (0.2-6) Bq/kg.
 

 

Some Mechanical Properties Of Polyvinylalcohol / Zinc Oxide Nanoparticles As Thin Films And Solutions

Najla Ali Elgheryani

Journal of University of Anbar for Pure Science, 2021, Volume 15, Issue 2, Pages 87-93

The polymer was dissolved in twice distilled water, then nanoparticles were added to it. The flow time of the solutions was measured, then the viscosity was calculated and the surface tension of the solutions was measured by measuring the weight of the liquid drop. Solutions were left at room temperature to form thin films that were subjected to variable tension until they were cut and depending on the stress and strain of the samples. From the results, an increase in the stress borne by the samples was noted with an increase in the concentration of zinc oxide nanoparticles, and express the departure from the ideal elastic behavior has values ranging from 3.71 to 54, but quantity pertaining to the ideal elastic behavior has values ranging from 1.2 to 1.0. Increase viscosity of the solutions and their surface tension. This makes it clear that it is possible to change some properties of the PVA by adding zinc oxide nanoparticles, the sum of Huggins and Kraemer constants values indicates that the samples were dissolved in a good solvent, as they can be used in many areas of life such as industrial, medical applications.
 

 

A linear relation to calculate one particle expectation value for 1S2 configuration for 2< Z <100

WISSAM AHMED AMEEN

Journal of University of Anbar for Pure Science, 2012, Volume 6, Issue 1, Pages 51-56

One particle expectation value for 1S2 configuration for Z =2 to 10 are evaluated by using Hartree-Fock-Roothaan (HFR) wavefunction. A linear relation are determined to describe these results, and this relation have tested to check its ability to calculate one particle expectation value for atoms with higher atomic numbers (Z = 2 to 100). Results are in good agreement with calculations given by [S.L. Saito Atomic Data and Nuclear Data Tables95, (2009) ,836-870] for Z<20.

Compared Some Water Characteristics of Tigris River With Euphrates River

Sabah Obaid Hamad

Journal of University of Anbar for Pure Science, 2015, Volume 9, Issue 3, Pages 191-200

: A number of physical and chemical ambient water characteristics of the Tigris and Euphrates rivers were studied on a monthly basis over the year (2011). Samples through 61 sampling station was collected, which distributed by 39 stations along the Tigris river and 22 station along the Euphrates river. Samples collected were analyzed to find a number of variables. The variables measured include cations group (Ca, Mg Mg, Na Na), anions group (Cl, SO4), nitrate NO3, phosphate PO4, total dissolved solids TDS, in addition to measuring pH.Data were analyzed statistically to extract the results. Results showed that average concentrations of calcium ions to the Tigris River 69 mg /L, and the Euphrates River 139 mg /L. The average concentration of magnesium ions of the Tigris River is 34 mg /L, while of the Euphrates River is 67 mg /L. Average concentration of sodium ions of the Tigris River is 58 mg /L, and the Euphrates River is 247 mg /L. Average concentration of sulfate ions of the Tigris River is 154 mg /L, and the Euphrates River is 425 mg /L. Average concentration of chloride ions of the Tigris River is 98 mg / L, and the Average of the Euphrates River is 375 mg /L. Average concentration of nitrate ions of the Tigris River is 3.48 mg /L and the same average value registered to the Euphrates River. Phosphate ions concentration rate of the Tigris River is 0.24 mg / L, and the Euphrates River is 0.20 mg /L. Average concentration of total dissolved solids of the Tigris River is 530 mg / L, while the Euphrates River is 1419 mg /L. Average pH value of the water for the Tigris River is 7.6 and 7.8 for Euphrates River. Water quality of the Tigris and Euphrates rivers varies from one section to another. Water quality is better in the upstream sections of the rivers. There is a general trend to increase salinity and degradation of water quality whenever river stream Turn south because of decreasing water level and accumulation of pollution loads. Water quality of the Tigris generally better than the quality of waters of the Euphrates, where many tributaries supply Tigris river with freshwater inside Iraqi territory while Euphrates River exposed to different effluent inside Syrian territory before entering the Iraqi border. Recorded values of most variables measured of the Euphrates river greater than the values of Tigris River at the beginning of the entry of the rivers into the Iraqi border. Euphrates River compared with the Tigris River was exposed to different effluent discharges especially agricultural discharge in the central and southern regions in addition to changing hydrological conditions.

Scientific Astronomical Criteria for the Crescent Visibility and Actual sighting.

Majeed M. Jarad

Journal of University of Anbar for Pure Science, 2008, Volume 2, Issue 3, Pages 148-152

The main goal to which we aspire is to reach a unified scientific astronomical
criteria in order to determine the possibility of a sighting of the crescent newborn which
support by the majority of astronomers and scholars of religion in order to work on the
standardization of our events Islamic religious sites, as is the case in determining the
beginning of the holy month of Dhul Hijjah, which does not differ by two in the Islamic
world. To reach such criteria requires cooperation between the scientific astronomers and
the religious scholars in order to narrow the differences and inequalities that often
happening. The differences could be two days and in some cases three days. In this study
we offer some observations and recommendations on this subject.

Effect Of Whey Protein Supplement On Biochemical Parameters in Building Body Athletes

Amal K. Abbas; Qasim M. Fathi

Journal of University of Anbar for Pure Science, 2017, Volume 11, Issue 3, Pages 21-25

This study was conducted to investigate the adverse effect of whey protein supplement taken by athletes on some biochemical parameters which include B.urea, creatinine, uric acid and lipids profile, LDH enzyme and C-reactive protein. Seventy-five Blood sample were collected from athletes whose take supplements of whey protein (experiment group), and twenty five blood sample of athletes who don’t take the supplement (control group), for the period from December 2016 to June 2017. The results show a significant increase (P < 0.05) in the levels of uric acid, serum creatinine and blood urea as compared with control group. On the other hand, the results show a significant increase (P < 0.05) in the levels of triglycerides (TG) and lactate dehydrogenase (LDH) in experimental group as compared with the control group, while no significant increase in the level of cholesterol , HDL and LDL in the experimental group as compared with the control group. Finally , the results demonstrate a significant increase (P < 0.05) in the level of C-reactive protein (CRP) activity of experimental group compared with control group. It was concluded from this study that whey protein supplement had an adverse effect on the level of uric acid, B.urea, creatinine, triglycerides, LDH enzyme, C-reactive protein.

Molecular Detection of fnbA, fnbB and nuc Genes and Phenotypic Detection of some Virulence Factors in Local Staphylococcus aureus Isolates.

Alaa Th. Ahmed; Safaa A. Latef; Ismail H. Aziz

Journal of University of Anbar for Pure Science, 2017, Volume 11, Issue 3, Pages 8-16

In this study, Staphylococcus aureus (S. aureus) isolates (32) were collected from different hospitals in Baghdad and were diagnosed by conventional methods. Antimicrobial susceptibility test was performed by disc diffusion method for ten antibiotics. Hemolytic production activity and Deoxy ribonuclease (DNase) production ability were detected. The biofilm production ability was detected by microtiter plate method. The diagnosis was confirmed using PCR to detect the thermostable nuclease gene (nuc). Then, PCR technique was used to detect the fibronectin binding protein A and fibronectin binding protein B genes (fnbA and fnbB respectively).
The results showed a high prevalence (78%) of Methicillin-resistant Staphylococcus aureus (MRSA) isolates, Imipenem and vancomycin were the most affective antibacterial agents tested. All isolates produced DNase enzyme . On blood agar plate, 65.6% of isolates produced β-hemolysis zones while (34.4%) of isolates did not produce any hemolytic zone. The results of biofilm production assay showed that 41% of isolates gave a weak positive results. All isolates (100%) that had been previously diagnosed as S. aureus by routinely used methods harbored the nuc gene. fnbA and fnbB were found in (100%) and (25%) of isolates respectively.
Conclusion: Molecular detection of nuc gene by PCR has high specificity for identifying S. aureus with a low cost which requires less time as compared with biochemical methods. fnbA and fnbB genes are important virulence factors of S. aureus. fnbA gene is the highest prevalence of toxinogenic and can be used as a genetic marker for diagnosis of local S. aureus isolates while fnbB gene does not play an important role in infection of S. aureus.

THE EFFICIENCY OF CRUDE EXTRACT FOR LOCAL PLANTAGO OVATE IN BLOOD COAGULATION

S. H. AHMED; J. A. OBAID; H. O. ABID; N. H. MOHAMMAD

Journal of University of Anbar for Pure Science, 2011, Volume 5, Issue 3, Pages 35-39

This study was performed on the seed of the local plant plantago ovata which grow naturally in Iraq . Water and ethanolic
extract of this seed are prepared. Two groups of laboratory mice are used in addition to another as control. The laboratory
tests are done on blood samples from these mice , included calculate the time of brothrombin , coagulation and platelet
count using different concentration of both water and ethanolic extracts of this plant. The results revealed the water extract
of (20 and 30) mg/ml caused a decrease in clotting time. Also the low concentration of crude extracts (water and ethanolic)
were very efficient to decrease in clotting time, and increase platelet count .
Key words: Plantago ovate,

Molecular Detection of fnbA, fnbB and nuc Genes and Phenotypic Detection of some Virulence Factors in Local Staphylococcus aureus Isolates.

Alaa Th. Ahmed; Safaa A. Latef; Ismail H. Aziz

Journal of University of Anbar for Pure Science, 2017, Volume 11, Issue 3, Pages 8-16

In this study, Staphylococcus aureus (S. aureus) isolates (32) were collected from different hospitals in Baghdad and were diagnosed by conventional methods. Antimicrobial susceptibility test was performed by disc diffusion method for ten antibiotics. Hemolytic production activity and Deoxy ribonuclease (DNase) production ability were detected. The biofilm production ability was detected by microtiter plate method. The diagnosis was confirmed using PCR to detect the thermostable nuclease gene (nuc). Then, PCR technique was used to detect the fibronectin binding protein A and fibronectin binding protein B genes (fnbA and fnbB respectively).
The results showed a high prevalence (78%) of Methicillin-resistant Staphylococcus aureus (MRSA) isolates, Imipenem and vancomycin were the most affective antibacterial agents tested. All isolates produced DNase enzyme . On blood agar plate, 65.6% of isolates produced β-hemolysis zones while (34.4%) of isolates did not produce any hemolytic zone. The results of biofilm production assay showed that 41% of isolates gave a weak positive results. All isolates (100%) that had been previously diagnosed as S. aureus by routinely used methods harbored the nuc gene. fnbA and fnbB were found in (100%) and (25%) of isolates respectively.
Conclusion: Molecular detection of nuc gene by PCR has high specificity for identifying S. aureus with a low cost which requires less time as compared with biochemical methods. fnbA and fnbB genes are important virulence factors of S. aureus. fnbA gene is the highest prevalence of toxinogenic and can be used as a genetic marker for diagnosis of local S. aureus isolates while fnbB gene does not play an important role in infection of S. aureus.

A COMPARATIVE STUDY OF ORAL AND TOPICAL KETOCONAZOLE IN THE TREATMENT OF PITYRIASIS VERSICOLOR

ABDULLAH S. HESSEN

Journal of University of Anbar for Pure Science, 2007, Volume 1, Issue 2, Pages 1-9

: Objective:-The first purpose of the present work is in vivo (clinical study): A comparative study of oral and topical Ketoconazole in the treatments of P V and (second) in vitro (laboratory study): To determine the activity of Ketoconazole against M Furfur by (MIC) test. Study patients:- In vivo or clinical study included only one hundred and seventy eight outpatients. Each patient was examined clinically before treatment as well as by laboratory examination.. After treatment, cure was confirmed by wood’s light examination , 95 % of cases were no fluorescence while direct microscopic examination showed cure of first degree 64 % , 44 % , 40 % , 12 % in groups A , B , C , D respectively for yeast and for hyphae cure was100% ,100% , 100 % , 84 % in groups A , B , C , D respectively. Results: - With regard antifungal susceptibility test (MIC), our results showed that Ketoconazole was highly effective against 40 isolates of the fungus with MIC ranging from 0.03 – 0.5 µg/ml. MIC50 was 0.06 µg/ml and MIC90 was 0.25 µg/ml. However drug acts as fungicidal action (MFC) in 19 (47.5 %) of isolates and fungistatic action (MIC) in 21 (52.5 %) of isolates. The study concluded that ketoconazole was highly effective in vivo and in vitro., clinical trial reported the great cure in group A (200mg) followed by group B (400mg), then group C (2% cream) and group D (2% shampoo) was the less cure. Also, great side effect in group A followed by C, D then B.

STUDYING THE VIBRATION FREQUENCIES OF CORANNULENE AND IT'S POSITIVE AND NEGATIVE RADICAL IONS USING QUANTUM MECHANICAL CALCULATIONS

REHAB M. KUBBA; MANAL AL-DELEIMY; MUTHANA SHANSHAL

Journal of University of Anbar for Pure Science, 2011, Volume 5, Issue 2, Pages 32-48

The vibration frequencies, IR absorption intensities and normal coordinates of the
Corannulene radical cation and anion were calculated applying the MINDO/3, PM3, (DFT (B3LYP/6-
311G)) quantum mechanical methods. The results allowed proper assignments for the frequencies of
the experimentally known, radical cation vibrations. They provided pre estimation of the radical anion
frequencies. Comparison is done for the frequencies of the ions with those of the neutral Corannulene
molecules.

Study of Hormonal levels changes in women’s serum with polycystic ovaries syndrome (PCOS)

Mustafa Nuhad Jumaa; Nafea Ahmed Saood

Journal of University of Anbar for Pure Science, 2011, Volume 5, Issue 1, Pages 17-23

This study was done in Fallujah Hospital and AL-Jameaa medical Lab in Fallujah city since the beginning of February of 2009 until June 2009. Hormonal changes in the serum of polycystic ovary syndrome (PCOS) infertile women in Fallujah city and there countryside’s were studied. Forty infertile women affected with increase of testosterone were selected, twenty of them with (PCOS) compared with twenty normal women. All of the women in this study from Fallujah city and surrounded area with different ages. All women showed the same symptoms, like hair growth in face, bold voice with an increase in testosterone and increase in LH while there no differences in FSH level. The levels of Prolactin was increased at (12.5%) .In conclusion the high levels of testosterone is responsible of hirsutism studeid in women lead to presence of the secondary characters of men in women and this because of high levels of in free androgens which lead to the increase estrogen in esteron form that make a appositive feed back on LH secretion which lead to increase testosterone secretion from the ovary.

Journal Information

Publisher: University of Anbar

Email:  juaps@uoanbar.edu.iq

Editor-in-chief: Omer H.shehab

About Journal

Journal of University of Anbar for Pure Science (JUAPS) is dedicated to publish research papers from all disciplines of pure science. Subject areas cover, but are not limited to, physics, chemistry, biology, environmental sciences, Earth sciences, biotechnology, nanotechnology, mathematics and computer...
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