Sulaf Mustafa Mohammed
Abstract
Abstract : Human exposure to lead continues to be a serious public health problem, because lead can cause renal disease and the kidney has the highest concentrations among the soft ...
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Abstract : Human exposure to lead continues to be a serious public health problem, because lead can cause renal disease and the kidney has the highest concentrations among the soft tissues. Exposure to lead is associated with adverse effects on renal function in laboratory animals and man. An experiment was conducted to study the effect of oral feeding of lead acetate on kidney by estimation the levels of uric acid, urea and creatinine in the serum of mice and the histological parameters of kidney in three different durations. Mice were treated with 0.4 mg/100 ml lead acetate (LA) for 10 days (group A) and for 20 days (group B) and for 30 days (group C).levels of urea in the serum of group A, B, and C increased significantly comparing with the control group, also there was significant differences between group A and group B and between group A and group C, but there was no significant differences between Group B and group C. Level of serum uric acid in groups A, B, C increased significantly comparing with the control group but there was no significant differences among treated group.Serum creatinine levels in group A increased none significantly comparing with the control group. While increased significantly in both of group B and group C, there was significant differences between group A and group C, but there was no significant differences between group A and group B.Kidney sections in group A characterized by foci of congestion and heamorrhage.Glomerular swelling revealed in the kidneys of group B, but the kidney of group C revealed vasculitis, heamorrhage and early hyalinization, normal gromeruli appear in all treated groups.
