Sabri M. Hussain; Mohammed Q.Al-Ani; Khalid F.Al-Rawi; Mahmood. M.Atia
Abstract
This study aimed to determine the prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in Al-Anbar Governorate-Ramadi and to study the different relationships between these ...
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This study aimed to determine the prevalence of Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency in Al-Anbar Governorate-Ramadi and to study the different relationships between these cases and different haematological parameters values. In addition to that this study aimed to investigate the degree of G6PD deficiency in both sever and moderate status and to find the ratio of this enzyme deficiency in both sexes .One hundred sixty six (166) samples from both sexes (80) males and (86) females(neonates) were collected. Results showed that the overall frequency among neonates of G6PD deficiency was 10.84% (13.75% males and 8.13% females.Significant difference in G6PD deficiency was found between both sexes, males showed more frequency than females (P< 0.01.) Males showed high ratio of acute G6PD deficiency than females (P< 0.01), vise versa for the moderate G6PD deficiency. The normal G6PD activity level, mean ± standard deviation among neonates was (10.85±0.88) IU/gm.Hb.,this mean activity value was (9.77±0.82)IU/gm.Hb.for males and (11.93±0.95)IU/gm.Hb.for females, while this value among neonates with G6PD deficiency was (1.59±0.120)IU/gm.Hb.,for males (0.98±0.063)IU/gm.Hb.and (2.21±0.187)IU/gm.Hb. for females respectively.Patients with G6PD deficiency neonates showed significantly lower (P< 0.01) haemoglobin (Hb), packed-cell volume (PCV), red blood cell count (RBC) and enzymatic activity values than G6PD normal subjects.While Reticulocyte count was higher in the samples of neonates with G6PD deficiency but this increase was not significant in comparison to the normal neonates. (P> 0.05)Also non significant differences (P> 0.05) were found between samples of normal individuals and those of G6PD deficiency regarding white blood cell count (WBC) .
