Document Type : Research Paper

Authors

1 Tikrit University - College of Science

2 Tikrit University - Collage of Education

10.37652/juaps.2014.122633

Abstract

This study aimed to determine some physiological and hormonal factors cause women infertility in Samarra. Studying sample included 70 random women who effected infertility whom ages are (18-45)years old. These women go to the private clinics in Samarra. The blood samples taken during the period of (2-4) days of the menstrual cycle The studied samples is compared with control group of (20) healthy women. The age groups of infected women are specified as highest average within (27-36) years, then from (18-26) years, then from (37-45) years respectively. The study includes determination the concentration of: Inhibin B, Follicle Stimulating Hormone (FSH),Luteinizing Hormone(LH), Testosterone (Testo.), lipid profile such as Cholesterol (Chol.), Triglycerides (TG), high density lipoprotein Cholesterol (HDL-C), low density lipoprotein Cholesterol(LDL-C), and very low density lipo protein Cholesterol (VLDL-C), and body mass index (BMI).The results showed that there is significant increase at level (P≤0.05), in the concentration of hormones FSH, LH, Testo., and also in the concentration of Chol., TG, LDL, VLDL, and BMI in the infertility women in comparison with control group, Respect to Inhibin B, showed significant decrease in infertility women when compared with control group, while HDL, showed non significant differences between two study groups. According to the age groups ,the study shows that there is significant increase in the concentration FSH, LH,Testo., Chol., TG, LDL, VLDL, and BMI in the infertility women in comparison with control group , However Inhibin B showed asignificant decrease in infertility women in comparison with control group.HDL showed non significant differences between two groups except the age group (27-36) which showed a significant decrease between groups.

Keywords

Main Subjects

1.Agarwal, A & Saleh, R.A. (2004). Role of free radicals in female reproductive diseases and assisted reproduction. Reproduction biomedicine online, www. Rbmonline. Com . RBM online; 9, NO.3,338-347.
2.Gnoth C, Godehardt E, Frank-Herrmann P, Friol K., Tigges J., Freundl G.(2005). Definition and prevalence of subfertility and infertility. Hum. Repro.:1144-1147.
3.Dohle, G. R.; Jungwirth, A.; Colpi, G.; Giwercman, A.; Diemer, T.; Hargreave, T. B.(2007). Guide lines on male infertility. European Association of Urology.
4. الراس ، مصطفى أحمد (2001) . العقم عند المرأة  (کتاب الکترونی) ، صحة للمعلومات الطبیة والصحیة
5.Balasch, J. (2000). Investigation of the infertility couple .Hum . Repro. 15:2251_2257.
6.Agarwal A, Gupta S &  Sharma R (2005). Role of oxidative stress in female reproduction. Repro. Biol. Endocrinol; 3: 28.
7.Krajcir N., chowdary H., Gupta S. and Agaewal A. (2008).Female infertility and assisted Reproduction =Impact of oxidative stress .Current womens Health Reviews 4: 9_15.
8.Blackwell, R.E and Azziz, R. (2006). Essential Reproductive Medicine . 9th ed . MC Graw Hill copanies . pp: 359 – 413
9.Shccron, N.C and Linda, H.B. (2006). Infertility Counseling .2nd ed Cambridge. pp;22-43.. 
10.Gurnee and Crystal, L, Illinois. (2009). Infertility with Polycystic ovaries. Advanced Fertility Center of Chicago, S.C. (847) : 662-1818.
11.Talia Edar. (2010). Testesteron , Role in infertile by treatment . Roole of Both Good and Evil. ; J. Endocrinol..(162):177-181.
12.Bourgeois, FJ.; Gehrig, PA. and Veljovich, DS. (2005). Obstertrics and gynecology recall. 2nd ed. Lippin cott Williams and wilkins Com. USA. pp: 281-283.
13.Roberston , D.M. ; Devosf, L. ; Fould , L.M. ; Mclachlan , R.I. ; Burger , H. G. Morgan , F.J. ; Hearn , M.T. and Dekrester, D.M.(2004) Isolation of  kDa from of inhibin from bovine follicular fluid , J. Molecular cell endocrinol Vol.(44):271-277.
14.Bristow AF. (1998). Standadisation of protein hormone immunoassays: current controversies. Proceeding of the UK NEQAS Endocrinology Meeting, ACB, 3: 66-73
15.Lenton , E. Meal, L. and Sulaiman, R.        (1982). Plasma concentrations of Human Gonadotropin from the time of Implantation until the second week of pregnancy . Fertility and sterility 37. 773-778 .
16.Vitt, U. A. ; Kloosterboer, H. J.; Rose, U. M. ; Mulders, J .W. ; Kiesel, P.S ,Bete, S.; Nayudu, P.L. (1998). Isoforms of human recombinant Follicle –Stimulating hormone: comearis on effects on murine follicle development  in vitro . Biol Reprod 59 ,854-861.
17.Tietz, N. W. (1999). Text book of clinical chemistry ,3rd  Ed C. A .Burtis , E R Ash wood , W .B. Saunders . pp: 826 -835.
18.Fried wald , W .T ; Levy , R . I . and Fredrickson , D. S. (1972) .Estimation of the concentration of low density lipoprotein cholesterol in plasma without use of preparation ultra centrifuge. Clin . Chem ; 18: 499-502.
19.Burtis,C.A and Ashwood E.R. (1999). Textbook of clinical chemistry.  3rd ed. W. B. Saunders Company, Tokyo. pp.: 1034-1054.
20.WHO. (2003). Obesity. Preventing and managing the global epidemic. Report of a WHO Consultation. WHO Technical Report Series 894. Geneva.WHO.
21.الراوی ، خاشع محمود . (2000) . مدخل إلى الإحصاء . الطبعة الثانیة . دار الکتب  للطباعة والنشر – جامعة الموصل.
22.Emokpae MA, Vadia PO, Mohammed AZ.(2005). Hormonal evaluations and endometrial biopsy in infertile women Annals. Afrmed, 4 (3), 99–103.
23.نادر, ریم ادیب محمد (2010 ). دراسة العلاقة بین هرمون الانهبین و العقم لدى النساء فی مدینة تکریت و ضواحیها.رسالة ماجستیر.کلیة العلوم .جامعة تکریت.
24.عبد الله، آمنة احمد طایس .(2011). دراسة فسلجیة ،کیمیوحیویة لدى النساء  العقیمات و السلیمات فی محافظة صلاح الدین.رسالة ماجستیر. کلیة ألتربیه/ جامعة تکریت .
25.الجمیلی, أفراح قاسم صالح.(2012). مقارنة تراکیز هرمونات الأنهبین ومضاد المولارین وعدد من الهرمونات الاخرى لدى النساء فى مدینة کرکوک . اطروحة دکتوراه. کلیة ألتربیة /جامعة تکریت.
26.Reyftman, L.;Dechaud, H.;Ovtchnikoff .(2003). Amenorrhea an arteriovenous uterine malformation and recovery of menses after emboliztion . Reprot. Bio.Med. Online. Oct. 7(3) : 327-9.
27.Groome, NP.; IIlingworth, PJ; O'Brein, M; Cooke, I; Ganesan, Ts and Baird, DT. (1994). Detection of dimeric inhibin throughout the human menstural cycle by two-site enzyme immuno assay. Clin. Endocrinol., 40: 717-723.
28.Dipiro and Harris , W. (2007) Pharmacitherapy Physiology , J. Clin. Endo. and Meta. Vol.(82) 131.
29.AL-Shalah. H and AL-Hilli N.(2010). Procalcitonin as a Mediator of Chronic  Inflammation in Obese Women with PCOS. Med. J. Babylon. 7. 505-510.
30.عبد الرزاق, لینا قیس یاسین (2010) ,دراسة عدد من المعاییر الدمویة والکیموحیویة  وبعض الهرمونات لدى النساء العقیمات فی  محافظة صلاح الدین. رسالة ماجستیر,کلیة العلوم\جامعة تکریت.
31.Olooto, W,E. Adeleye, A, O. Amballi, A, A. and Mosuro, A, O. ( 2012). Pattern of Reproductive Hormones (Follicle Stimulating Hormone, Luteinizing Hormone, Estradiol, Progesterone, and Prolactin) Levels in Infertile Women in Sagamu South Western Nigeria. Scholars Research Library Der Pharmacia Lettre, Vol 4 (2):549-553.
32.Fischtach , ; Boazhir Shterg. M.D. ; Michael , ; Conn, Ph.D ; Gabriel , I. and Lynnette. (2000). Ectopic luteinizing hormone secration and Anovulation , J. England Medicin.(23):348-4.
33.الدوری ، ساریا ناجی محسن . (2007). دراسة هرمونیة وکیموحیویة و فلسجیة على عدد من النساء المصابات بمتلازمة تکیس المبایض المتعدد فی مدینة تکریت وضواحیها . رسالة ماجستیر . کلیة العلوم . جامعة تکریت .
34.Thomas, M.A. and Rebar, R.W. (1997). Delayed puberty in girls and primary amenorrhea. Current Therapy in Endocrinol. Met. 6, 233-226.
35.Erden HF; Zwain IH; Asakura H; Yen SSC. (1998). Corticotropin-releasing factor inhibits luteinizing hormone-stimulated P450c17 gene expression and androgen production by isolated theeal cells of human ovarian follicles, J. Clin. Endocrinol.Metab .83:448.
36.Speranda. Z. and Papic. Z.(2004). Effect of increased Testosterone level on woman´s fertility.Preliminary Communication, pp;(53-58).
37.Robert, F.  Schmidt, Ftorianlong, Gerhard. (2010). Physiology edes men schen : Mitpatho. Physiology . 1st ed Hill Proffsional , pp:496.
38.Mustafa Torgal ; Arifkokcu ; Mehmet , B . ; Cetinkaya, ; Tayfun alper ; and Erdal Malatya. (2005).  Dobasal inhibin A and inhibin B  level  have value in the dignosis of polycyctic ovary syndrome, J. Gynocology Endocrinol . Vol. (20) No.(6):322-326.
39.Giovanni De Pergola, ; Simona Maldera,;Massimo Tartagni,; Nicola Pannacciulli, ; Giuseppe Loverro and Riccardo Giorgino. (2006). Inhibitory Effect of Obesity on Gonadotropin, Estradiol, and Inhibin B Levels in Fertile Women.
40.Halder A, Fauzdar A, Ghosh M, Kumar A. (2007). Serum inhibin B: Adirect  and precise marker of ovarian function.. J.Clin.diagno. Res.;3:131-137.
41.Mehta , K. N. Parik, K.H. Chag, M.C. and Shah, V. G .(2003). Effect of Treatment on homocysteine in cardiac patients : a prospective study . Indian J. of pharma, 35: (5). 410 .
42.Corter-Rudellj , C. ; Pingny , P. ; Decante , C. (2002). Obesity and serum luteinzing hormone level have an independent and oppositive effect on the serum inhibin B level in patents with P.C.O.S., J. Fertil. Steril..(77):281-287
43.Saija, M.D. Maritta, M.D. Leo, M.D. M, auno vanhala, M.D and Seppo Saari-koski, M. D. (2001). Relationship of the metabolic Syndrome and obesity to polycystic ovary Syndrome acontrolled population based study . Am. J. obstet.  Gyne.Gol; 184 : 289-96.
44.Bronk R.(1999). Human metabolism functional diversity and     integration. 4th ed . Addison Wesley Longman Limited., pp.228.
45.Huxley, R.R. ; Neil, H.A. (2003). The relation between dietary cholesterol intake and coronary heart disease mortality : ameta – analysis of prospective cohort studies . Euro . J. Clin. Nutr.57:904-908.
46.Bizzi, P Dessole, S. Tonolo, G. Gapotianco, G. Milial, Puddul, Nardol, G. (2003). Effect of ovarian stimulating on plasma lipid and polylipoprotein contrations in apopulation of infertilite women underogeng.N C.B.I. ; 7(3):309-12.
47.Helena, E M.; Helen, R. and Monty, K .(2001). Abnormal lipoprotein metabolism and reversible female infertility in HDL receptor (SR-BI)–deficient mice; Am.Soci.Clin.Invest  . 108(11): 1717-1722.