Document Type : Research Paper
Authors
College of Science, University of Anbar
Abstract
This research included the estimation the concentration hemoglobin and the levels of some its derivatives which include the Oxyhaemoglobin, Methamoglobin, Carboxyhaemoglobin and Sulfhaemoglobin in the blood of women during delivery (90 sample) and compared it with 90 samples of their levels in the umbilical cord blood of their newborns (43 female and 47 male). The samples of this research were collected from the newcomer women to the general hospitals of Al-Fallujah and Al-Ameria and their newborns ,women ranged in age from 18-40 years old and who are apparently healthy, and included both natural (vaginal) and caesarean delivery. The findings of this research reached to find high significantly differences (P≤0.01) in haemoglobin levels for the group of women during delivery and newborn with average (11.676 ± 1.0) and (16.566 ± 1.8) g/dl at the succession.Also it finds high significantly diferences (P≥0.01) between the levels of Hemoglobin in women blood during the delivery compared with those of their newborns. Their levels reached (0.611 ± 0.1 , 0.604 ± 0.1 , 0.557 ± 0.9 , 0.530 ± 0.9) for each derivative of Oxyhaemoglobin, Methmoglobin, Carboxyhaemoglobin and Sulfhaemoglobin at the succession in women blood during the childbirth. While their levels reached to (0.783 ± 0.13 , 0..768 ± 0.13 , 0.721 ± 0.11 , 0.677 ± 0.12) in the umbilical cord blood of their newborn for the same derivatives at the succession.It also found a simple positive correlation (r = 0.259) between each of the concentration of the haemoglobin of the mother and haemoglobin of their newborns and found that the weight of the mother influence the values of rates of the derivatives Carboxyhaemoglobin and Methmoglobin for the newborns, as values were significantly higher (P=0.05) in category gravimetric (60-50) kg , compared with other categories of these derivatives, while the derivative of the Oxyhaemoglobin arose significantly(P=0.05) in the age group (80 and over) kg. While the haemoglobin and its derivatives not affected both in the blood of newborns with the age of mother , type of delivery, and sex , weight of the newborns.
Main Subjects
- Guyton, A. C. and Hall, J. E. (2006). Textbook of medical physiology. 11th Edition, Elsevier Saunders, Philadelphia. USA.
- Fialova, L. and Vejrazka, M. (2010). Hemoglobin and its derivatives. Iron. Rev. J. Med. Pp:1-14.
- دیب،جرجس (2009). علم الدمویات. جامعة دمشق.
- Fronticelli, C.; Sanna, M. T.; Alvarado, G. G.; Karavitis, M.; Lu, A. L. and Brinigar, W.S. (1995). Allosteric modulation by tertiary structure in mammalian hemoglobins. J. Biol. Chem. 270(51):30588-30592.
- Fox, S. I. (2006). Human Physiology. 9th Edition. Mc. Graw-Hill. New York, USA.
- Zijlstra. W. G.; Bunrsma, A. and Roest, W. D. (1991). Absorption spectra of human fetal and adult oxyhemoglobin, deoxyhemoglobin, carboxyhemoglobin and methemoglobin. Clin. Chem. 37(9):1633-1638.
- Wright, R. O.; Lewander, w. J. and Woolf, A. D. (1999). Methemoglobinemia : etiology, pharmacology and clinical management. Ann. Emerg. Med. 34(5):646-656.
- Fan, A. M. and Steinberg, V. E. (1996). Health implication of nitrite in drinking water، an update on methemoglobinemia occurrence and reproductive and developmental toxicity .Regul. Toxicol. Pharmo.; 23:35-43.
- Atyabi, N.; Yasini, S. P.; Jalali, S. M. and Shaygan, H. (2012). Antioxidant effect of different vitamin on methemoglobin production :an in vitro study. Veter. Res. Forum. 3(2):97-101.
- Portier, C. J. (2012). Toxicological profile for carbon monoxide. 1st edition, Health and Human Services. USA
- Bassem, M. R.; Samir, W. A. and Saleh, N. (2007). Hemoglobin oxygen affinity of Egyptian obese smokers suffering from elevated non-functional hemoglobin derivatives .Zool.2(1):9-14.
- Baranoski, G. V.; Chen, T. F.; Kimmel, B. W.; Miranda, E. and Yim, D. (2012). Noninvasive optical monitoring and differentiation methemoglobinemia and sulfhemoglobinemia reflectance. J. Bio. Optica. 17(9): 3-14.
- Triapirux, V.; Kitlttipogvivat, P. C. and Chalajit, S. (2008). Methemoglobin and sulfhemoglobin levels in students of Walailak university. Wala. J. Sci. Tech. 5(2):173-180.
- Drabkin, D. L. and Austin, J. H. (1935). J. Biol. Chem. 112-151.
- المشنی، یوسف وفطایر، عبد الرحیم (1999). الکفایات العملیة لتخصص فنیو المختبرات الطبیة. دار الثقافة والتوزیع. عمان-الأردن.
- Duncan, D. B. (1995). Multiple range and F-test . Biomertic;11:42.
- Heidemann, B. H.(2000). Changes in maternal physiology during pregnancy . Anaesth. Rev. ;12:42-44.
- Cunningham, F. G.; Leveno, K. J.; Bloom, S. L.; Hauth, J. C.; Rouse, D. J.; and Spong, C. Y. (2010). Williams Obstetrics .3rd edition، Mc Graw Hill, New York.
- Wu, L. and Wang, R. (2005). Carbon monoxide : endogenous production, physiological functions and pharmacological application. Pharm. Rev. 57(4):585-630.
- Suhail, S.; Patil, S.;Khan, S. and Siddiqui, S. (2010). Antioxidant vitamins and lipoperoxidation in non-pregnant, pregnant and gestational diabetic women : Erythrocytes Osmotic fragility profiles. J. Clin. Med. 2(6):266-273.
- Gomez, C.; Berlin, I.; Marquis, P. and Delcorix, M.(2005). Expired air carbon monoxide concentration in mothers and their spouses above 5ppm is associated with decreased fetal growth. Prev. Med.; 40:10-15.
- Wang, R.; Wang, Z. and Wu, L. (1997). Carbon monoxide induced vasorelaxation and the underlying mechanisms. Brit. J. Pharm.; 121:927-934.
- Kilbride, J.; Baker, T. G.; Parapia, L. A.; Khoury, S. A.; Shuqaidef, S. W. and Jerwood, D. (1999). Anaemia during pregnancy as a risk factor for iron-deficiency anaemia in infancy: a case-control study in Jordan. Int. J. Epid.; 28:461-468.
- Pee, s.; Bloem, M. W.; Sari, M.; kiss, L.; Yip, R. and Kosen, S.(2002). The high prevalence of low hemoglobin concentration among Indonesian infants aged 3-5 months is related to maternal anaemia.. Am. J. Nutr. Sci. Pp:2215-2221.
- Paiva, A. D.; Rondo, P. H.; Pagliusi, R.A.; Lattore, M. D.; Cardoso, M. A. and Gondim, S.R. (2007). Relationship between iron status of pregnant women and their newborns. Rev. Saude Publica. 41(3):321-327.
- الحسنی, ضیاء حسن والهیتی, محمد أمین(1990). فسلجة الحیوان . مطابع التعلیم العالی. جامعة بغداد.
- Gomez, C.; Berlin, I.; Marquis, P. and Delcorix, M.(2005). Expired air carbon monoxide concentration in mothers and their spouses above 5ppm is associated with decreased fetal growth. Prev. Med.; 40:10-15.
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