“Synthesis and Characterization of same Imide Schiff’s bases Derived for Trimethoprim and their biological evaluation”

F. Mesher, Mohammad; H. Khalaf, Yousif; A. Abbas Alheety, Jalal

doi:10.37652/juaps.2014.124119

Document Type : Research Paper

Authors

¹ College of Science, University of Anbar

² University of Anbar - College of Pharmacy

³ College of Science, University of Anbar-Ramadi

https://doi.org/10.37652/juaps.2014.124119

Abstract

Synthesis and characterization mono imides derivatives for trimethoprim, through reaction of the later with one mole of maleic and phthalic anhydrides, using the classical reflux methods in addition to the microwave technique in the presence of glacial acetic acid. Conversion of mono imides derivatives prepared in (1) above to the Schiff`s bases by the condensation with substituted aromatic aldehydes or ketones, using conventional method and microwave technique. So that imides-imines derivatives have been prepared. All the compounds prepared above have been characterized by using the physical constant by recording the malting points and using the spectroscopic methods such as UV-Visible, FT-IR and H1NMR spectroscopy. Study the biological activity of some selected new compounds as anti-bacterial against four types of bacteria (Pseudomona aruginons , Escherichia coli , Staphylococcus aureus and Enterococcus faecalis) isolates by Biomerixe co. using the disk diffusion method. This study showed high biological activity of most prepared compound against the studying bacteria.

Main Subjects

Chemistry

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Journal of University of Anbar for Pure Science

“Synthesis and Characterization of same Imide Schiff’s bases Derived for Trimethoprim and their biological evaluation”

References

References

Volume 8, Issue 3
December 2014
Page 91-97

“Synthesis and Characterization of same Imide Schiff’s bases Derived for Trimethoprim and their biological evaluation”

References

References

Volume 8, Issue 3December 2014Page 91-97

Volume 8, Issue 3
December 2014
Page 91-97