Document Type : Research Paper

Authors

1 University of Anbar - College of Science

2 University of Anbar - College of Pharmacy

10.37652/juaps.2015.124379

Abstract

The study aims at finding out some the affecting factors on the infection with the Helicobacter pylori . It also includes age since the highest rate was for age group (11-20 years). The factor of sex has also an effect because females showed a higher proportion of infection over males of 70% and 30 % respectively. The kind of food has relation to the development of the H.pylori with percentage 37%. Smoking has also relation to the infection of 26%. There was also a relationship between the infection and the place of residence because the percentage of infection in villages is higher than in towns of 60% and 40% respectively. The study also concentrates on some immune diseases associated with infection of the H.pylori. since there is a relationship between the infection H.pylori and diabetes of 40%.

Keywords

Main Subjects

  1. 1. Marshall B.J. ; and Warren , J.R., (1984) . unidentified curved bacilli on gastric epithelium in active chronic gastritis. Journal Lancet; Vol. 1: pp. 1311-1315.

    2. Hong, LU ; and Shu,  Dong XIAO , (2014) . New ideas for future studies of Helicobacter pylori . Journal of Digestive Diseases, Vol. 15: pp. 1-4 .

    3. Garza-Gonzalez, Elvira ; Perez-Perez, Guillermo Ignacio ; Maldonado-Garza , Héctor Jesús ; and Bosques-Padilla , Francisco Javier , (2014) .  A review of Helicobacter pylori diagnosis, treatment, and methods to detect eradication. journal World J Gastroenterol , Vol.  20 , No. 6 :  pp. 1438-1449.

    4. Atheron , John C.,(1998) .H.pylori virulence factors . Journal , British medical Bulletin ; NO .1 : pp 105 - 120 .

    5. Cover, T.L. ;  and Blaser, M.J., (2009). Helicobacter pylori inhealth and  disease Journal Gastroenterology.,Vol.136: pp. 1863-1873.

    1. Luigina, Cellini1; Rossella ,Grande; Luciano , Artese; and Leonardo, Marzio.,(2010). Detection of Helicobacter pylori insaliva and esophagus . 33, 351-357.

    7. Kalaf ,  Elham Abdulhadi , (2013) . Molecular Study for Detection of CagA Genotype of Helicobacter pylori from Endoscopic Biopsies of Iraqi Patients . University of Baghdad .

    8. Ali  , Sama Fakhri , (2013) . Detection of Helicobacter pylori in saliva from some Iraqi patients in comparison with other methods . University of Baghdad .

    9. Ashok, Kumar ; and Imran , Khan.,(2010).Detection of Helicobacter pylori in Gastroduodenal Diseases by Real TimePCR.  170-178.

    10. Zsikla, V. ; Hailemariam, S.  ; and Baumann, M., (2006) Increased rate of Helicobacter pylori infection detected by PCR in biopsies with chronic gastritis. Journal The Am.J. of Surgical Pathology., Vol. 30 , No.  2 : pp.  242–248 .

    11. Arkckila ,P.E. ; Seppala , K. ; Kosunen , T.U. ; Sipponen, P. ; Makinen, J. ; Rautelin , H. ; and Farkkila, M. , (2005). Helicobacter pylori eradication as the sole treatment for gastric and duodenal ulcers. Eur. Journal Gastroenterol. Hepatol , Vol. 17: pp.93-101.

    12. Wong, B.C.;  Lam,  S.K. ; Wong, W.M. ; Chen, J.S.; Zheng, T.T.; Feng, R.E. ; Lai, K.C.; Hu, W.H.; Yuen , S.T.; Leung ,S.Y. ; Fong, D.Y.; Ho, J. ; Ching , C.K. ; and Chen, J.S., (2004). Gastric Cancer Study Group: Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. Journal JAMA , Vol. 291: pp.187-94.

    13. Wong , B.C.; Zhang , L.; Ma, J.L. ; Pan, K.F. ; Li , J.Y.; Shen , L. ; Liu , W.D. ; Feng , G.S. ; Zhang, X.D. ; Li, J . ;  Lu , A.P. ; Xia , H.H. ;  Lam, S. ; and You , W.C. , (2012). Effects of selective COX-2 inhibitor and Helicobacter pylori eradication on precancerous gastric lesions. Journal Gut , Vol. 61: pp. 812-818.

    14. Brown, L.M. , (2000). Helicobacter pylori: Epidemiology and routes of transmission. Journal Epidemiol. Rev., Vol 22: pp.238-297.

    15. Fukuda , K . ; Kuroki , T. ; Tajima , Y. ; Tsuneoka m N. ; Kitajima , T. ; Matsuzaki , S. ; Furui , J. ; and Kanematsu , T. , (2002) . Comparative analysis of Helicobacter DNAs and biliary pathology in patients with and without hepatobiliary cancer . Journal Carcinogenesis , Vol. 23 , pp. 1927 – 1931.

    16. Bakir,  Wasan A. , (2007) . Immunological and Molecular Studies on Gastroduodenal Diseases Caused by Helicobacter pylori . University Anbar .

    1. 17.  Suerbaum ,S. ; and Michetti , P. , (2002) . Helicobacter pylori infection. Jornal N Engl J Med, vol. 347: pp. 1175–1186 .

    18. Boyanova, L. ,(2011). Helicobacter pylori. Journal Caister Academic press . ISBN 978-1-904455-84-4 .

    1. 19.  Simona , Cardaropoli ; Alessandro ,  Rolfo ; and Todros Tullia , (2014) . Helicobacter pylori and pregnancy-related disorders . Journal  World J Gastroenterol ; Vol. 20, No. 3: pp 654-664.

    20. Fock, K. ; and Leong Ang, T. , (2010). Epidemiology of Helicobacter pylori infection and gastric cancer in Asia. Journal Gastroenterol. Hepatol., Vol. 25: pp. 479–486.

    21. Atherton, J. , (2006). The pathogenesis of Helicobacrter pylori induced gastroduodenal diseases. Journal Annual Review of Pathology: Mechanisms of Disease., Vol. 1: pp.63.

    22. Pounder , R.E., Ng , D. (1995). The prevalence of Helicobacter pylori infection in different countries. Journal Alimentary Pharmacology and Therapeutics, Vol. 9, : pp. 33−39.

    23. Talley, N.J.; Vakil N.; Ballard , E.D. ; and Fennerty, M.B.; (1999) . Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia. Journal N Engl J Med , Vol. 341: pp. 1106– 1111.

    24. Konno, M.; Fujii, S.; Yokota, K.; Takahashi, E.; and Sugiyama, T., ( 2005). Five-year follow-up study of mother-to-child transmission of Helicobacter pylori infection detected by a random amplified polymorphic DNA fingerprinting method. Journal. Clin. Microbiol., Vol. 43: pp.2246-2250 .

    25. Kusters, J.; vanVliet, A.; and Kuipers, E.,  (2006). Pathogenesis of Helicobacter pylori infection. Journal Clin. Microbiol. Rev., Vol. 19: pp. 449-490.

    26. Jang, S.; Jones, K.; Olsen, C.; Joo, Y.; Yoo, Y.; Chung, I.; Cha, J. ; and Merrell S., (2010). Epidemiological link between gastric disease and  polymorphisms in VacA and CagA. Journal Clin. Microbiol., Vol. 48: pp. 559–567.

    27. Yamaoka, Y. , (2009). Helicobacter pylori typing as a tool for tracking human migration.Journal Clin. Infect., Vol. 15: pp.829–834.

    1. 28.  Rimbara, E. ; Sasatsu , M. ; and Graham , D.Y., (2013) . PCR detection of Helicobacter pylori in clinical samples. Journal Methods Mol Biol, Vol. 943:pp. 279-287 . [PMID: 23104297 DOI: 10.1007/978-1-60327-353- 4_19].
    2. 29.  Abu-Sbeih , Ruba S.; Hawari,  Azmi D. ; Hassawi Dhia S.; and  Al-Daghistani Hala I. , (2014) . Isolation and detection of  Helicobacter pylori  from patients suffering from peptic ulcer using biochemical tests and molecular techniques . American Journal of Biochemistry and Biotechnology Vol.  10 , No. 1:  pp. 58-68 .
    3. 30.  Al-Saadi, A. M. ; Al-Khayat, J. Q. ; Muhammad, I. M. ;and Anwar, S. A., (2004).The role of Helicobacter pylori in esophagitis and peptic ulcer disease in Iraq. Journal Saudi. Med. , Vol. 25: pp.1216-1222.

    31. Zhu, Yangchun; Zhou, Xiaoying; Wu Junbei, Su Jing ; and Zhang, Guoxin, (2014) .Risk Factors and Prevalence of Helicobacter pylori Infection in Persistent High Incidence Area of Gastric Carcinoma in Yangzhong City .Jornal Gastroenterology Research and Practice , Volume 2014, Article ID 481365 http://dx.doi.org/10.1155/2014/481365 .

    32. Shokrzadeh, L. ; Baghaei , K.;  Yamaoka , Y.; Shiota, S.; Mirsattari, D. ; Porhoseingholi, A. ; and Zali , M.R. , (2012) . Prevalence of  Helicobacter pylori infection in dyspeptic patients in Iran. Jornal Gastroenterol Insights , vol.  4 : pp. 24–27 .

    1. 33.  Bodner,  C.; Andersen, W. J. ; Reid ,T.S. ; and  Godden, D. J. , (2000)  . Childhood  exposure to infection and risk of adult onsetwheeze and atopy . Journal  Thorax, vol. 55, No. 5,: pp. 383–387.

    34. Aguemon , B. D. ; Struelens, M. J. ; Massougbodji, A. ; and  Ouendo , E. M. , (2005). Prevalence and risk-factors for Helicobacter pylori infection in urban and rural Beninese populations . Journal Clinical Microbiology and Infection, vol. 11, No. 8, : pp. 611–617 .

    1. 35.  Hauge, T. ; Persson, J. ; and Daneilsson, D., (1997). Mucosal bacterial growth in the upper gastrointestinal tract in alcoholics. Journal Dig., Vol. 58: pp. 591-595.

    36. Nagini, S. , (2012). Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. Journal World. J. Gastrointest. Oncol., Vol. 4: pp.156-169.

    37. Gonzalez , C.A., ;  and Lopez-Carrillo L., (2010) . Helicobacter pylori, nutrition and smoking interactions: their impact in gastric carcinogenesis. Journal Scand J Gastroenterol, Vol. 45: pp. 6–14.

    1. 38.  Endoh, K. ; and Leung, FW., (1994). Effects of smoking and nicotine on the gastric mucosa: a review of clinical and experimental evidence.Journal Gastroenterol., Vol.107: pp. 86478.
    2. 39.  Tsugane, S. ,  (2005) Salt, salted food intake, and risk of gastric cancer:epidemiologic evidence . Journal Cancer Science, vol. 96, No. 1,: pp. 1–6 .

    40. Alizadeh , A.H.M. ; Ansari, S.; Ranjba , M.; and et.al., (2009). Seroprevalence of Helicobacter pylori in Nahavand: a population based study. Jornal Eastern Mediterranean Health , vol. 15, :pp. 129-5.

    41. Valliani ,A. ; Khan, F.; Chagani , B ; and et.al., (2013). Factors associated with Helicobacter pylori infection: results from a developing country-Pakistan. Jornal Asian Pac J CancerPrev, vol. 14 : pp. 6 – 53.

    42. Abebaw, Wubejig ; Kibret , Mulugeta ; and Abera , Bayeh ,(2014) . Prevalence and Risk Factors of  H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study .Jornal Asian Pac J Cancer Prev,volume , Vol. 15 , No. 11 : pp. 4459 - 4463 . DOi: http: //dx.doi. org/ 10.7314/APJCP .2014.15.11.4459.

    43. Sasidharan, S. ; Lachumy S.T.; Ravichandran, M. , et.al., (2010). Epidemiology of  Helicobacter pylori among multiracial community in Northern Peninsular, Malaysia: effect of age across race and gender. Jornal, Asian J Trop Med, vol. 45 : pp. 5- 72.

    44. Tadesse, Endale ; Daka , Deresse ; Yemane, Demo; and Shimelis, Techalew  ,( 2014 ). Seroprevalence of  Helicobacter pylori infection and its related risk factors in symptomatic patients in southern Ethiopia  . Jornal BMC Research Notes . Doi: http://www.biomedcentral.com/1756-0500/7/834.

    45. Seyda , T.; Derya , C. ; Fusun , A.; and  Meliha, K. , (2007) . The relationship of Helicobacter pylori positivity with age, sex, and ABO/Rhesus blood groups in patients with gastrointestinal complaints in Turkey. Jornal  Helicobacter , vol. 12 , No. 3: pp. 244–250.

    46. Kibru ,Dargaze ; Gelaw, Baye ; Alemu  , Agersew ; and Addis, Zelalem , (2014) . Helicobacter pylori infection and its association with anemia among adult dyspeptic patients attending Butajira Hospital, Ethiopia . Jornal BMC Infectious Diseases . Doi:http: //www. biomedcentral. Com /1471-2334 /14/656 .

    47. He , Cong ; Yang,  Zhen ; and Lu, Nong-Hua  , (2014) . Helicobacter pylori infection and diabetes: Is it a myth or fact? .Jornal World J Gastroenterol, vol. 20 , No.16: pp. 4607-4617 . doi:10.3748/wjg.v20.i16.4607 .

    48. Borody, T. ; Ren,  Z. ; Pang , G. ; and Clancy,  R. , (2002) . Impaired host immunity contributes to Helicobacter pylori eradication failure. Jornal Am J Gastroenterol; vol.  97  : pp.  3032-3037. [PMID: 12492186 DOI: 10. 1111 /j. 1572 -0241 .2002.07121.x].

    49. Jeon ,C.Y.; Haan , M.N.; Cheng, C.; Clayton, E.R.; Mayeda, E.R.; Miller, J.W.; and Aiello, A.E.,( 2012) Helicobacter pylori infection is associated with an increased rate of diabetes. Jornal Diabetes Care, vol.  35:  pp. 520-525. [PMID: 22279028 DOI: 10.2337/dc11-1043] .

    50. de Luis, D.A.; de la Calle , H. ; Roy, G. ; de Argila , C.M. ; Valdezate , S. ; Canton, R. ; and  Boixeda , D., (1998) . Helicobacter pylori infection and Insulin-dependent diabetes mellitus. Jornal Diabetes ResClin Pract, vol. 39:pp. 143-146. [PMID: 9597384].

    51. Gentile , S. ; Turco , S. ; Oliviero , B. ; and Torella ,  R., (1998) . The role of autonomic neuropathy as a risk factor of Helicobacter pylori infection in dyspeptic patients with type 2 diabetes mellitus. Journal ClinDiabetes Res Pract, Vol. 42: pp. 41-48. [PMID: 9884032].

    52. Aydemir, S. ; Bayraktaroglu, T. ; Sert , M. ; Sokmen , C.; Atmaca , H. ; Mungan, G. ; Gun , B.D.; Borazan , A. ; and Ustundag,  Y., (2005) . The effect of Helicobacter pylori on insulin resistance. Jornal Dig Dis Sci , Vol. 50: pp.2090-2093. [PMID: 16240220 DOI: 10.1007/s10620-005-3012-z].

    53. Kayar ,Yusuf ;  Pamukçu , Ozgul ; EroLlu, Hatice ; Erol, Kubra Kalkan;  Ilhan, Aysegul ; and Kocaman,  Orhan , (2015) . Relationship between Helicobacter pylori Infections in Diabetic Patients and Inflammations, Metabolic Syndrome,and Complications . Journal  International  Journal  of Chronic  Diseases, Vol. 2015, Article ID 290128, 6 pages . http://dx.doi.org/10.1155/2015/290128.