Document Type : Research Paper
Authors
1 University of Anbar - College of Science
2 Ministry of Science and Technology - Department of Materials
3 University of Anbar - Histology Branch
Abstract
Objective: The present study was undertaken to investigate the chemopreventive efficacy of amygdalin and magnetic water during the initiation phase of 1, 2-dimethylhydrazine (DMH) induced colon carcinogenesis in a rat model.Methods: Seven groups of ten rats each were selected for the study. Group I animals treated as control. Group II rats received for DMH (20 mg/kg body weight) injections subcutaneously once a week for 16 consecutive weeks and then kept without any treatment till the end of the experimental period. Group III rats received amygdalin (20mg/100mg) daily via Oro-gastric tube. Groups IV was given magnetic water freely. Group V was given DMH+Amg. Group VI was given DMH+M.W. Finally, group VII was given DMH+Amg+M.W. Histological changes in the colon were studied.Results: In the study of light microscope the following results were observed: In DMH group was observed hyperplastic aberrant crypt foci of colorectal mucosa and hyperchromatic nuclei. The larger gland are significantly more pleomorphic and hyperchromatic. A mucinous carcinoma with a wide infiltration of submucosa. While a normal appearance of histological structure of colon in other groups were observed.Conclusion: From these results we can conclude that the treatment 1,2-dimethylhydrazine has a negative effect, and the amygdalin and magnetic water reflects an important role in the inhibition of colon cancer.
Main Subjects
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