Document Type : Research Paper

Author

University of Baghdad - College of Science

Abstract

Pregnancy-induced hypertension (PIH) is responsible for significant maternal and prenatal morbidity, liver function affected by this disease. Liver function tests ( LFTs ), namely S.ALP, S.AST, S.ALT, Albumin, Bilirubin and prothrombin time were evaluated in forty hypertensive pregnant women, forty healthy pregnant women along with forty aged matched non pregnant women as a control who attended to Hospital, the results showed that: S.ALP, S.AST, S.ALT and Bilirubin were significantly higher (P<0.001) in hypertensive pregnant women when compared to normotensive and control, albumin was significantly lower (P<0.001) in hypertensive pregnant when compared to normotensive and control whereas prothrombin time did not give significantly different between the studied groups.

Keywords

Main Subjects

  1. Sonagra AD, Dattatreya k, Murthy J. Serum LDH, ALP and Uric acid in Hypertensive Disorder of pregnancy. Int J Pharm Bio Sci 2(3):201-209, (2012).
  2. Mitra AK, Patki PS, Mitra SK. Liver disorders  during pregnancy and their management. The Antiseptic 105(4): 193-196, (2008).
  3. Blackburn ST,Loper DL.Maternal,fetal and neonatal physiology. Aclinical perspective.Philadelphia:Saunders, (1992).
  4. VanThiel DH,Gavaler JS.Pregnancy associated sex steroids and their effects on the liver.Semin Liver Dis 7(2): 1-7, (1987).
  5. Coppage KH, Sibai BM. Treatment of hypertensive complications in pregnancy. Curr Pharm Des 11(6): 749-757, (2005).
  6. Lojo Mission JF, Caughey AS. Hypertensive disease of pregnancy and maternal mortality. Curr Opin Obstet Gynecol. 25(2):124-132,(2013).
  7. Raddi SA, Nayak BS, Prakash R, Puri R, Metgud MC. Stress, coping strategies and lived experience of women with pregnancy induced hypertention.  South Asian Federation of Obstetrics and Gynecology. 1(1):65-68,(2009).
  8. Mackay AP, Berg CJ, Atrash HK. Pregnancy related mortality from preeclampsia and eclampsia. AM J Obstet Gynecol 97(4):533-538, (2001).
  9. Kamath S. Hypertension in pregnancy. JAPI 54: 269-270, (2006).
  10. Munazza B, Raza N, Naureen A, Khan SA, Fatima F, Ayub M, Sulaman M. Liver function tests in preeclampsia. J Ayub Med Coll Abbottabad 23(4):3-5, (2011).
  11. Guntupalli RS,Steingrub J.Hepatic disease and pregnancy:An overview of diagnosis and management.Crit Care Med 33(10.Suppl.):332-339,(2005).
  12. Rahman TM,Wendon J.Sever hepatic dysfunction in pregnancy.QJ Med 95:343-357,(2002).
  13. pregnancy hypertension. In : Cunningham F, Lenevo K, Bloom S, Hauth J, Gilstrap L, Wenstrom K, edts. Williams Obstetrics, 23rd edn. MC Graw Hill, New York, pp706-728.(2011).
  14. Danial,W.W.Hypothesis testing.In:Biostatistic A foundation  for analysis in the health science.London.Wiley J and Sons;Third edition.161. (1983).
  15. Davison J, Homuth V, Jeyabalan A, Conrad K, Karumanchi A, Quaggin S. New aspects in the pathophysiology of preeclampsia. J Am Soc Nephrol 15: 2440-2448, (2004).
  16. Bell M. Historical overview of preeclampsia-eclampsia. J Obstet Gyencol Neonatal Nurs., 39(5): 510-518, (2010).
  17. Alonso AG. Effect of pregnancy on pre-exiting liver disease physiological changes during pregnancy.Annals of Hepatology: 5(3):184-186,(2006).
  18. Guntupalli RS,Steingrub J.Hepatic disease and pregnancy:An overview of diagnosis and management.Crit Care Med: 33(10.Suppl.):332-339,(2005).
  19. Loganathan G,Rachel G,Eapen CE.Liver function tests in normal pregnancy:astudy from Southern India. Indian J of gastroenterology .24(6):268-269,(2005).
  20. Bera S, Gupta S, Saha S, Kunti S, Biswas S, Debdatta G. Study of liver enzymes especially lactate dehydrogenase to predict foetal outcome in pregnancy induced hypertension. Sch. J. App. Med. Sci. 2(5A):1569-1572,(2014).
  21. Das S, Char D, Sarkar S, Saha TK, Biswas S, Rudra B. Evaluation of liver function test in normal pregnancy and preeclampsia: a case control. IOSR-JDMS: 12(1): 30-32,(2013).
  22. Knapen  MF, Mulder TP, Bisseling JG, Penders RH, Peters WH, Steegers EA. Plasma glutathione-s-Transferase Alpha-1-1. A more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorder of pregnancy. Am. J.Obstet Gynecol. 178(1):161-165.(1998).
  23. Asimuakopoulos G. pregnancy and liver diseases. Rev Med Chir Soc Med Nat Iasi. 110(2): 326-333.(2006).
  24. Harish K, Nitha R, Harikumar R, Sunil Kumar K, Varghese T, Bushrath K, Sandesh K, Tony J. Prospective evaluation of abnormal liver function tests in pregnancy. Trop Gastroenterol. 26(4): 188-193.(2005).
  25. Smith LG, Moise KH, Dildy GA, Carpenter RJ. Spontaneous rupture of liver during pregnancy: current therapy. Obstet Gynecol. 77:171-175,(1991).
  26. Chandy CL.Morgan M,Haunsworth I,Kinghman JGC.Prospective study of liver dysfunction in pregnancy in Southwest Wales.Gut;51:876-880,(2002).