Document Type : Research Paper
Authors
1 University Of Anbar - College of Education for Women
2 University of Baghdad - College of Science for Women
3 University of Anbar - College of Education for Girls
Abstract
This work includes synthesis and characterization of new derivatives of pyrimidine (R. or Ar. -1, 2, 3, 4-tetrahydropyrimidin-5-yl) ethan-1-one), via the reaction of acetyl acetone with different aldehydes and guanidine hydrochloride. Using absolute ethanol as a solvent .This mixture was refluxed for (6– 20) hrs.at pH 6 we prepared .The same derivatives of pyrimidine were prepared in microwave way. This compounds were prepared characterized by melting point, FT-IR , UV-Vis and some of the with 1H-NMR and 13C-NMR spectroscopy .
Keywords
Main Subjects
- Zhao, X. L., Zhao, Y. F., Guo, S.-C., Song H. S. Wangand D. and Gong P.,(2007 ) “Synthesis and anti-tumour activities of novel [1,2,4] triazolo [1,5-a]pyrimidines”. Molecules, 12, 1136–1146.
- Cordeu L., Cubedo E., Bandrés E., Rebollo A., Sáenz X., Chozas H., Domínguez, M.V., Echeverría, M., Mendivil, B., Sanmartin, C., Palop, J. A., Font, M. and García-Foncillas, J.(2007) “Biological profile of new apoptotic agents based on 2,4,-pyrido[2,3-d]pyrimidine derivatives. Bioorg”. Med. Chem., 15, 1659–1669.
- Sharma, P.; Rane, N.; Gurram and V. K. , Synthesis QSAR(2004, ) “studies of pyrimido[4,5-d]pyrimidine2,5-dione derivatives as potential antimicrobial agents. Bioorg”. Med. Chem. Lett. 14, 4185–4190.
- Dos Anjos J. V. ,MendonçaJr F. J. B., Costa-Silva J. H. ,de Souza I.A., MeloS.J. and Lat. Am. J. Pharm., (2008), 27 p. 343.
- White D. C., Greenwood T. D., Downey A. L.,Bloomquist J. R., and Wolfe J. F. (2004) ,Bioorg. Med. Chem., 12, pp. 5711–5717.
- Dos Anjos J. V., Srivastava R. M., Costa-Silva J. H. , Scotti L., Scotti M. T., Wanderley A. G., Leite E. S., Melo S. J. and Junior F. J. B. (2012), , Molecules, 16 pp. 809–819 .
- Saladino R., Ciambecchini U., Maga G., Mastromarino P., Conti C. and Botta M. A. (2002), Bioorg. Med. Chem. Lett., 10 , pp. 2143–2153.
- Yamaguchi M. , Wakasugi K., Saito R., Adachi Y., Yoshikawa Y., Sakurai H., and Katoh A. (2006), Inorg J. Biochem., 100 ,pp. 260–269.
- Elkholy Y. M. and Morsy M. A. Facile (2006) “Synthesis of 5,6,7,8-Tetrahydropyrimido[4,5-b]-quinoline Derivatives”. Molecules, 11, 890–903.
- Holla B. S., Mahalinga M. , Karthikeyan M. S., Akberali P. M. and Shetty N. S. (2006)“Synthesis of some novel pyrazolo[3,4-d]pyrimidine derivatives as potential antimicrobial agents”. Bioorg. Med. Chem. 14, 2040–2047.
- Ingarsal N., Saravanan G., Amutha P. and Nagarajan S. (2007) ,Synthesis, in” vitro antibacterial and antifungal evaluations of 2-amino-4-(1-naphthyl)-6-arylpyrimidines” .Eur. J. Med .Chem. 42, 517–520.
- Sharma P., Rane, G. N. and Synthesis V. K. ( 2004) QSAR” studies of pyrimido [4,5-d] pyrimidine2,5-dione derivatives as potential antimicrobial agents. Bioorg. Med. Chem. Lett., 14, 4185–4190.
- Kandil S. S., Katib S. M., Yarkandi A. and Trans N. H. M. Met.( 2007) Chem., 32, 791-798
- Elkholy, Y. M. and Morsy M. A. , (2006) “Synthesis of5,6,7,8-Tetrahydropyrimido [4,5-b]-quinoline Derivatives”. Molecules, 11, 890–903.
- Augusto L. X., Alfredo M. S. , Emerson P. da S. F. and Janaína V. dos A. (2013 ) “Antinociceptive pyrimidine derivatives: aqueous multicomponent microwave assisted synthesis”Volume 54, Issue 26, 26 June, Pages 3462–3465.
- Ehsan S. , Ishfaq A. , Khan B., Saghi T. and Ghafoor S.( 2012),"Conventional and Microwave – Assisted Synthesis and Antimicrobial evaluation of pyrimidine Azo compounds" , International J.of science and research ", 3(12),P.368-373 ,.
- Xavier A. L., Simas A. M. ,Falcao E. S. and dos Ajos J.V., (2013. )“Antinociceptive pyrimidine derivatives :aqueous multicomponent microwave assisted synthesis” Tetrahedron Letters 54, 3462–3465 ,
- Srivastara V. (2013.).,"An Improved protocol for BiginelliReaction",Green sustainable Chemistry ,3,P.(38-40) ,
- Mitra M. and Oliver K. (2007) “Microwave-Assisted Solution- and Solid-Phase Synthesis of 2-Amino-4-arylpyrimidine Derivatives” J. Comb. Chem., 9 (2), pp 275–284.
)
