Document Type : Research Paper

Authors

1 College of Education / University of Anbar

2 College of Science / University of Anbar

10.37652/juaps.2008.15300

Abstract

The aim of this study is to determine the changes in GOT and GPT
enzymes activity in hepitaitis patients . Results showed that the increasing in
both enzymes activity is different between male and female in both GOT & GPT
47.93 I.U/L in male and 53.10 I.U/L in female and 73.31 I.U/L male and 69.42
I.U/L in female respectively . The reason of this increasing is belong to the
damage of liver cells by hepatitis virus.

Keywords

1- Dixon, M and Webb E.C. In "Enzymes". 2nd Ed, long man, London P. 54, 1964.
2- Green D. E. In "Enzymes and Enzymes system" Harvard University Press, Cambridge, London. P. 15, 1951.
3- Thompson, R. H. S. and Woollon, I.D.P. in "Biochemical Disorder in Human Diseases", 3rd Edn. London, PP. 711-712, 1970.
4- Davidson. I. and Henry. J. B. In "Toddsantotd clinical Diagnosis by laboratory methods" 15th Edn. P. 871-874, 1974.
5- Popper, H. and Schanfther, F. In "Progress in Liver Diseases" New York and London, Vol 4 P. 184-185, 1972.
6- Chinsky, and Sherrys, J. Lab. Clini Med 47:108, 1965.
7- Kaplan. M. M. and Righett: A. J. clin Invest 49:508-516, 1970.
8- Young. I. I. Ann. New York Head Sci. 75:357-362, 1958.
9- Dixon, T. F. and Purdum M. J. clin Path, 7:341-343, 1954.
10- Al-Modhaffar, S. A. and AL- Salihi, F. G.: GOT Isoenzymes in normal human serum and their kinetics. Folia Biochemical et Biological Graeca. Vol. XIV. P. 35, 1978
11- Al-Modhaffar, S. A. and AL- Salihi, F. G.: Further Studies on GOT Isoenzymes I, II, III of normal human serum. Folia Biochemical et Biological Graeca. Vol. XIV. P. 44, 1978
12- Al-Modhaffar, S. A. and Hassan, F.: Ultracentrifugation analysis (SCHLIEREN MOVING BAND DIAGRAM) of glutamic aspartic transaminase (EG. 2.6.1.1.) Isoenzymes. Folia Biochemical ET Biological Graeca. Vol. XIV. P. 54, 1978
13- BOCHAROV, A. L., DEMIDKINA, T. V., KARPEISKII, M, Ya. And POIYANOVSKII: Selective modification of tyrosine and cysteine residues in aspartate amino transferase from pig heart cytosol. Bichem. Biophys. Res. Commun. 50, 377, 1973
14- BORST, P. and PETERS, E. M.: Intracellular localization of glutamate oxaloacetate transaminases in heart. Biochem. Biophys. Acta. 54, 188, 1961
15- BOYD, J. W. : the  Intracellular distribution, latency and electrophoretic mobility of L- glutamate-oxaloacetate transminase from rat liver. Biochem. J. 81, 439, 1961.
16- CORNISH-BOWDEN, A.: In Principle of enzyme Kinetics, IST Ed Butter Worth, London, P. 120, 1976.
17- DAWES, E. A: in comprehensive Biochemistry (florkin; M., and Stotz, E. H.) Vol. 12, Chap. IV, Elesevier, Amsterdam P. 104, 1964.
18- DIXON, M. and WEBB, C. E.: in Enzymes, 2nd ed., Longmans, London.P. 116, 1966
19- EISENTHAL, B. and CORNISH-BOWDEN, A.: A new graphical procedure for estimation of enzyme kinetics parameters. Biochem. J. 139, 715, 1974
20- FLEISCHER. G. A., POTTER, C. S. and WAKIM, K. G.: Proc. Soc. Exp. Biol. 103, 229, 1960
21- FLEISCHER. G. A. and WAKIM, K. G.: Disappearance rates of glutamic- oxaloacetic transaminase II (GOT II) under various conditions. J. Lab. Clin. Med. 61, 86, 1963
22- EBOTT, M. D.: in Microzone Electrophoresis manual, Bechkman instruments, California. 1973
23- HILL, A. V.: J. Physiol. 4, IV- VII, 1916
24- JENKINS, W. T., YPHANTIS, D. A. and SIZER, I. W.: Glutamic-aspartic transaminase I-Assay, Purification, and general properties. J. Biol. Chem. 234, 51, 1959
25- KALCKAR, H. M.: J. Biol. Chem. 167, 461, 1947
26- NISSEL BAUM, J. S. and BODANSKY, O.: Immunochemical and Kinetic properties of anionic and cationic glutamic-oxaloacetic transaminases separated from human heart and liver, J. Biol. Chem. 239, 4232, 1964