Synthesis ,Characterization and biological activity study of new Schiff's bases containing 3,4-dimethyl maleimide moiety

MaroufAl-Azzawi, Ahlam

doi:10.37652/juaps.2010.15522

Document Type : Research Paper

Author

Ahlam MaroufAl-Azzawi

University of Baghdad - College of Science

10.37652/juaps.2010.15522

Abstract

A series of new Schiff's bases containing 3,4-dimethyl maleimide moiety have been synthesized via multisteps synthesis including reaction of 3,4-dimethyl maleic anhydride with aniline producing N-phenyl-3,4-dimethyl maleimide which react with chlorosulfonicacid producing 4-(N-3,4- dimethyl maleimidyl )phenyl sulfonyl chloride which on amination with hydrazine hydrate yielded in turn 4- ( N-3 ,4 -dimethyl maleimidyl) phenyl sulfonyl hydrazine and this when condensed with various aromatic aldehydes and ketones afforded the desirable Schiff bases. Structures of the prepared compounds were confirmed by spectroscopic methods including FTIR, 1HNMR,C13NMR spectroscopy and C.H.N analysis.The synthesized Schiff's bases were screened for their antibacterial activity against three microorganisms:Staphylococcus aureus, Escherichia Coli, and Psedomonas aeruginosa. They were found to exhibit high antibacterial activity.

Keywords

Main Subjects

Chemistry

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Journal of University of Anbar for Pure Science

Synthesis ,Characterization and biological activity study of new Schiff's bases containing 3,4-dimethyl maleimide moiety

References

References

Volume 4, Issue 1
April 2010
Page 19-26

Synthesis ,Characterization and biological activity study of new Schiff's bases containing 3,4-dimethyl maleimide moiety

References

References

Volume 4, Issue 1April 2010Page 19-26

Volume 4, Issue 1
April 2010
Page 19-26