Document Type : Research Paper
Authors
1 Minstiry of Science and Technology/ Directorate of Chemical Research
2 Ministry of Science and Technology / Directorate of Chemical Research
Abstract
Abstract :The donor properties of the amino acid Methionine CH3 SCH2 CH2 CH (NH2) COOH (HMt), were investigated for a number of transition Metal Ions , Co(ذ ) , Ni(ذ ) , Cu(ذ), Zn( ذ ) , Cd(ذ ) , Hg( ذ) , Pb (ذ ) .Methionine behaves as on anionic ligand (Mt)and generally forms neutral complexes , M" Mt2 the metal attains its usual higher coordination number by linking with the( N) atom of – NH2 group and with one or both the(O) atom of the – COO- group .In these complexes the ( S) atom of the –S CH2 group is still available for coordination. To help in the structural study of Methionine complexes a number of complexes were prepared and investigated .The effect of Methionine with detoxic (Pb, Hg, Cd ) on Glutathione s- Transfers and MDA were investigated.
Keywords
Main Subjects
- A.J. stosick. J. Am. chem..Soc.,67, 365 (1985).
- B. M. low,F.J. Hirshfeld, and F.M.Richards, ibid., 81, 4412 (1959)
- L. G. Marzilli, S. O. Ano, F. P. Intini and G. Natile, “Slowing the Clock in Pt anticancer Drug Chemistry” J. the chemistry of metal ion in every day life, Aug. 30 4, (2002).
- A.A.Isab, W.Ashraf and M.I.Waser.”Redox and Reaction Gold (1) Drug with di sulfide and diselnide in aquose solutions” 228th American chemical society (paper no. 7332)Aug. (2004).
- A.Rosenberg, Acta chem.Scand., 10 , 840 (1956) .
E.M.Crook, Ed., Metal and Enzyme Activity , Cambridge unirersity Press, 1989