Document Type : Research Paper

Authors

1 Minstiry of Science and Technology/ Directorate of Chemical Research

2 Ministry of Science and Technology / Directorate of Chemical Research

10.37652/juaps.2009.15561

Abstract

Abstract :The donor properties of the amino acid Methionine CH3 SCH2 CH2 CH (NH2) COOH (HMt), were investigated for a number of transition Metal Ions , Co(ذ ) , Ni(ذ ) , Cu(ذ), Zn( ذ ) , Cd(ذ ) , Hg( ذ) , Pb (ذ ) .Methionine behaves as on anionic ligand (Mt)and generally forms neutral complexes , M" Mt2 the metal attains its usual higher coordination number by linking with the( N) atom of – NH2 group and with one or both the(O) atom of the – COO- group .In these complexes the ( S) atom of the –S CH2 group is still available for coordination. To help in the structural study of Methionine complexes a number of complexes were prepared and investigated .The effect of Methionine with detoxic (Pb, Hg, Cd ) on Glutathione s- Transfers and MDA were investigated.

Keywords

Main Subjects

  1. A.J. stosick. J. Am. chem..Soc.,67, 365 (1985).
  2. B. M. low,F.J. Hirshfeld, and F.M.Richards, ibid., 81, 4412 (1959)
  3. L. G. Marzilli, S. O. Ano, F. P. Intini and G. Natile, “Slowing the Clock in Pt anticancer Drug Chemistry” J. the chemistry of metal ion in every day life, Aug. 30 4, (2002).
  4. A.A.Isab, W.Ashraf and M.I.Waser.”Redox and Reaction Gold (1) Drug with di sulfide and diselnide in aquose solutions” 228th American chemical society (paper no. 7332)Aug. (2004).
  5. A.Rosenberg, Acta chem.Scand., 10 , 840 (1956) .

E.M.Crook, Ed., Metal and Enzyme Activity , Cambridge unirersity Press, 1989