Document Type : Research Paper
Authors
1 Laser and plasma institute, Baghdad University
2 College of Science, University of Anbar.
Abstract
:The photo transitions of Erythromycin 2-propionate dodecyl sulphate (C40H71NO14, C12H26O4S) using Nitrogen Laser beam have been studied at different periods of time. Different techniques have been used to analyze and identify final products. The results showed that photo transitions of Erythromycin - Estolate which measured by conductivity initially increased and then decreased with time especially at high pulse rate. While pH showed a different behavior and initially there was reduction in pH values by increasing the pulse rate. The kinetic study indicated that the rate of reaction is of the second-order type . The qualitative identification showed that the final products were; • First: 6-(4-Dimethylamino-3-O-propionyl –6-methyl- tetrahydro-pyran-2-yloxy)-14-ethyl-4-(5-hydroxy-4-methoxy-4,6-dimethy-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyl-oxacyclotetradeca-2,10-dione-7,12,13-propaniol dodecyl sulphate.• Second: 6-(4-Dimethylamino-3-O-propionyl –6-methyl- tetrahydro-pyran-2-yloxy)-14-ethyl-4-(5-hydroxy-4-methoxy-4,6-dimethy-tetrahydro-pyran-2-yloxy)-3,5,7,9,11,13-hexamethyl-oxacyclotetradeca-2,9-diene-2,7,10,12,13-pentaol dodecyl sulphate. The final products showed an existaence of enol group through a tautomerism reaction of keto enol.
Keywords
Main Subjects
- R.F. Doerge, Textbook of organic medicinal and pharmaceutical chemistry, 8th edition, Lippincott, London, 278, 1982.
- Kucers, S.M. Crows, I.F. Hoy and M.L. Grayson, The use of antibiotics, A clinical Review of Antibacterial, Antifungal and Antiviral . 5th edition the bath press , Britain , 606 , 1997 .
- V.E. Tyler, L. R. Brady and J.E. Robbers, Pharmacognosy, 9th. Edition, Lea & Febiger, U.S.A, 363, 1988.
- European pharmacopoeia [0552] , 3rd edition , 1998.
- M. Ebadi, Pharmacology, 3rd edition, congress cataloging, U.S.A, 1996.
- R.E. Martin, J.H. Bates, Atypical pneumonia, Inf Dis clin N Amer 5:585, 1991.
- S.O. Bergquist, S. Bernaunder, H. Dahnsjo, B. Suncelfo, J, Erythromycin in the treatment of pertussia; a study of bacteriologic and clinical effect pediatr Infect Dis, 6:458, 1987.
- K.M. Farizo, P.M. Strebel, R.T. Chen and et al, Fatal respiratory disease due to corynebacterium diphtheriae; case report and review of guidelines for management, investigation, and control, clin Infect Dis 16:59, 1993.
- CDC (Centers for Disease Control) Sexually transmitted diseases treatment guidelines, MMWR 42(No RR-14): 20, 47, 1993.
10. C.H. Ginsburg, H. F. Eichenwald, J, Erythromycin; a review of its uses in pediatric practice, Pediatr 89:872, 1976.
11. M.A. Masal, J, Erythromycin hepato – Sensitivity; a preliminary report of two cases, Med Aust 1:560, 1962.
12. M. Boguniewicz, D.Y.M. Leung, J, Hypersensitivity reactions to antibiotics commonly used in children, pediatr Infect Dis 14:221, 1995.
13. R.A. Schoenenberger, W. E. Haefeli, P. Weiss, R.E. Rits, J,Association of Intravenous erythromycin and potentially fatal ventricular tachycardia with Q.T. prolongation (torsades de pointes), Brit Med 300:1375, 1990.
14. M. Dan, D. Feigl, J, Erythromycin-associated hypotension pediatr Infect Dis 12:692, 1993.
15. R.K. Stoelting, pharmacology and physiology in anesthetic practice, Lippin cott, London, 466, 1987.
16. G.C. Rosenfeld, D.S. Loose and J.B. Jones, Broad Review series “ Pharmacology”, 3rd edition, Williams & Wilkins, U.S.A, 325, 1998.
17. R.C. Goldman, S.W. Fesikl and C.C. Doran, Role of protonated and neutral forms of macrolides in binding to ribosomes from Gram – positive and Gram negative bacteria. Antimicrob Ag chemother 34:426,1990.
18. E. Cundliffe., K.Mc Quillen, J., Bacterial protein synthesis, the effect of antibiotics, J. Mol Biol 30:137,1967.
19. N.L. Oleinick, J.W. Corcoran,J, Two types of binding of erythromycin to ribosomes from antibiotics-Sensitive and resistant Bacillus Subtilis 168 Biol chem 244; 727, 1969.
20. Vidal, Z. Dinya and F. Mogyorodi, Appl. Catal. B. environ, 259, 1999.
21. D. Mas, T. Hisanage, K. Tanaka and P. Pichat, J. photo chemistry, photo biology, 3:467, 1994.
22. H.M.K.K. Pathirona, R.A. Maithree pala, J. photo chemistry and photo biology A; chemistry, 102:273, 1997.
23. D.F. Ollis, H. AL-Ekabi, photo ctalytic purification and treatment of water and air, Elsevier science publishers B.V., 511, 601, 1993.
24. P. Theron, P. Pichat, chantal, C. petrier and T. Chropin, J. Phys. Chem. Chem. Phys., 1:4663, 1999.
25. S.T. Martin, C.L. Movrison and M.R. Hoffmann, J. phys. Chem., 98:13695, 1994.
26. R.T. Morrison, R.N. Boyd, Organic chemistry, 3rd edition, Allyn and Bacon, Inc., U.S.A., 261, 1973.
27. D.R. Palleros, Experimental organic chemistry, John Wiley & Sons, Inc., U.S.A., 421, 2000.
28. Sarkis,G.; J. Al-Rawi and J. Al-Gattia. Identification of chemical compounds. Baghdad University. 1981.
- 29. Shendalla, M. & Al-Jabouri N. Identification of organic compounds. Mousel University Iraq.1986.
30. Cotton and Wilkinson, Advanced Inorganic chemistry, A comprehensive text, 4th edition, 1980.
31. Sarkis, G. Spectroscopic methods of organic compounds. Baghdad University, Iraq.1986.
32. P. Crews, J. Rodriguez, Organic structure analysis, Oxford univ press, Inc., Oxford, 351, 1998.
- 33. Mohammad, R (1985). Spectroscopic methods of organic compounds. Salah Al-Dein University, Iraq.
- 34. K. Florey, Analytical profiles of drug substances, Vol. 8, Academic press, Inc., U.S.A., 162, 1979.
35. Vocal, Practical in Organic chemistry, 986, 1979.
- 36. F. Fieser, K.L. Williamson, Organic experiments, 5th edition, D.C. Heath and company, U.S.A., 76, 1983.
)
