Effect of age on some renal function tests, uric acid, and gamma glutamyl transferase (GGT) in sample of Iraqi men over 40 years

Ibrahim, Mustafa Salim; Abd, Ziad Hammad; AL- Rawi, Khalid Farouq

doi:10.37652/juaps.2022.171594

Document Type : Research Paper

Authors

¹ Medical Laboratory Techniques Department/ AL-Maaref University College

² College of medicine / University Of Anbar

³ College of science / University Of Anbar

https://doi.org/10.37652/juaps.2022.171594

Abstract

Background: The prevalence of some aging markers that is part of metabolic syndrome elements are increasing worldwide, and the renal function is a major goal of this syndrome. Aim: To correlate the age with some renal function tests (blood urea and serum creatinine), serum uric acid (S.UA) and serum gamma glutamyl transferase (S.GGT).Material and methods: This study involve 127 men apparently healthy (≥ 40 years old) were analyzed for blood urea, serum creatinine, uric acid and gamma glutamyl transferase by the spectrophotometer methods by use the previously prepared kits from linear chemicals company.. Results: The mean age of men was (55.535±10.738)years. The men under study were divided into four groups according to age: 46 men (36.22%) their age range were ≥40 years, 33 cases (25.984%), 28 case (22.047%) and 20 others (15.748%) were (50-59), (60-69) and (≥70) years respectively. The mean ± Std. Deviation of variables in study were B. urea (42.387±3.682) mg/dl, S. creatinine (1.004±0.158) mg/dl, S.UA (6.216±0.829) mg/dl, and S.GGT (28.844±7.741) U/l. Older age was significantly associated with increased in B. urea and S. creatinine, while no significant association was found between age and S.UA and S.GGT in Iraqi men at (P ≤0.05 for all factors).Conclusions: older men are more liable to have higher B. urea and S. creatinine, with no relation between age and the levels of both uric acid and GGT in serum of Iraqi men under study.

Keywords

Main Subjects

Biology

References

1- Veronica, G., and Esther, R. R. M. (2012). Aging, metabolic syndrome and the heart. Aging and disease, 3(3), 269.

2- Malik, S., Wong, N. D., Franklin, S. S., Kamath, T. V., Gilbert, J. L., Pio, J. R., and Williams, G. R. (2004). Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation, 110(10), 1245-1250.‏

3- Preuss, H. G., Mrvichin, N., Clouatre, D., Bagchi, D., Preuss, J. M., Perricone, N. V., and Kaats, G. R. (2017). General Lack of Correlations between Age and Signs of the Metabolic Syndrome in Subjects with Non-diabetic Fasting Glucose Values. Journal of the American College of Nutrition, 36(7), 556-564.‏

4- Baillargeon, J., Pollock, B. H., Kristal, A. R., Bradshaw, P., Hernandez, J., Basler, J., and Thompson, I. (2005). The association of body mass index and prostate specific antigen in a population-based study. Cancer, 103(5), 1092-1095.

5- Price, M. M., Hamilton, R. J., Robertson, C. N., Butts, M. C., and Freedland, S. J. (2008). Body mass index, prostate-specific antigen, and digital rectal examination findings among participants in a prostate cancer screening clinic. Urology, 71(5), 787-791

6- Feinfeld, D. A., Keller, S., Somer, B., Wassertheil-Smoller, S., Carvounis, C. P., Aronson, M., and Frishman, W. H. (1998). Serum creatinine and blood urea nitrogen over a six-year period in the very old. Geriatric nephrology and urology, 8(3), 131-135.

7- Larsson, M., Jagenburg, R., and Landahl, S. (1986). Renal function in an elderly population A study of S-creatinine, 51Cr-EDTA clearance, endogenous creatinine clearance and maximal tubular water reabsorption. Scandinavian journal of clinical and laboratory investigation, 46(6), 593-598

8- Lindeman, R. D. (1986). The aging kidney. Comprehensive therapy, 12(3), 43.‏

9- ‏Sivakumar, K., Thamarai, R., and Pragatha, R. J. (2014). Screening of serum uric acid in obese individuals in rural population. International Journal of Scientific Study, 2(2), 1-4.

10- Cain, L., Shankar, A., Ducatman, A. M., and Steenland, K. (2010). The relationship between serum uric acid and chronic kidney disease among Appalachian adults. Nephrology dialysis transplantation, 25(11), 3593-3599.

11- Lin, S. D., Tsai, D. H., and Hsu, S. R. (2006). Association between serum uric acid level and components of the metabolic syndrome. Journal of the Chinese Medical Association, 69(11), 512-516.

12- Bandaru, P., and Shankar, A. (2011). Association between serum uric acid levels and diabetes mellitus. International journal of endocrinology, 2011: 604715.

13- Facchini, F., Chen, Y. D. I., Hollenbeck, C. B., and Reaven, G. M. (1991). Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. Jama, 266(21), 3008-3011.‏

14- Kang, D. H., Park, S. K., Lee, I. K., and Johnson, R. J. (2005). Uric acid–induced C-reactive protein expression: implication on cell proliferation and nitric oxide production of human vascular cells. Journal of the American Society of Nephrology, 16(12), 3553-3562.

15- Shankar, A., Klein, R., Klein, B. E. K., and Nieto, F. J. (2006). The association between serum uric acid level and long-term incidence of hypertension: population-based cohort study. Journal of human hypertension, 20(12), 937.

16- Karakurt, Ö., Çağirci, G., and Eryaşar, N. E. (2011). Gamma-glutamyl transferase activity increases in prehypertensive patients. Turkish Journal of Medical Sciences, 41(6), 975-980.‏

17- Stojakovic, T., Scharnagl, H., Trauner, M., Pieske, B., Wellnitz, B., Seelhorst, U., and März, W. (2010). Serum gamma-glutamyl transferase and mortality in persons undergoing coronary angiography—The Ludwigshafen Risk and Cardiovascular Health Study. Atherosclerosis, 208(2), 564-57.

18- Talke, H., and Schubert GE (1965). Ezymatic urea determination in the blood and serum in the Warburg optical. Klin. Wochenschr. 43 : 174.

19- Jaffe M. (1886). Ueber den Niederschlag welchen Pikrinsa¨ure in normalen Harn erzeugt und u¨ber eine neue reaction des Kreatinins. Z Physiol Chem, 10: 391-400.

20- Barham, D. and Trinder, P. (1972). Improved Color Reagent for the Determination of Blood Glucose by the Oxidase System. Analyst, 97, 142-145.

21- IFCC (1983). Methods for the measurement of catalytic concentration of enzymes, Part 4. IFCC method for-γ-glutamyl transferase. Clin Chem Biochem. 21:643-646.

22- Ahamed, S. M., Modawe, G. A., Elsanni, B., and Ballal, M. A. (2013). Assessment of creatinine and urea blood levels in healthy volunteers. Sudan Medical Monitor, 8(3), 153.‏

23- Musch, W., Verfaillie, L., and Decaux, G. (2006). Age-related increase in plasma urea level and decrease in fractional urea excretion: clinical application in the syndrome of inappropriate secretion of antidiuretic hormone. Clinical Journal of the American Society of Nephrology, 1(5), 909-914.

24- Ganong, W. F., and Ganong, W. (1995). Review of medical physiology (p. 59). Norwalk, CT: Appleton and Lange.

25- Salive, M. E., Jones, C. A., Guralnik, J. M., Agodoa, L. Y., Pahor, M., and Wallace, R. B. (1995). Serum creatinine levels in older adults: relationship with health status and medications. Age and ageing, 24(2), 142-150.

26- Nilsson, S. E., Takkinen, S., Tryding, N., Evrin, P. E., Berg, S., McClearn, G., and Johansson, B. (2003). Association of biochemical values with morbidity in the elderly: a population‐based Swedish study of persons aged 82 or more years. Scandinavian journal of clinical and laboratory investigation, 63(7-8), 457-466.

27- Refsum, H. E., and Strömme, S. B. (1974). Urea and creatinine production and excretion in urine during and after prolonged heavy exercise. Scandinavian journal of clinical and laboratory investigation, 33(3), 247-254.

28- Marwah, S., Mehta, M., Shah, H., Haridas, N., and Trivedi, A. (2015). Correlation of serum uric acid and serum creatinine in hypothyroidism. National Journal of Physiology, Pharmacy and Pharmacology, 5(3), 232-235.

29- Adekola, S. A., Popoola, O. A., Ogundiran, S. M., Oparinde, D. P., Onuegbu, A. J. (2013). Is gamma glutamyl transferase a diagnostic marker of prostate disease?. International Journal of Medicine and Biomedical Research, 2(2), 147-151.

30- Pandur, S., Pankiv, S., Johannessen, M., Moens, U., and Huseby, N. E. (2007). γ-Glutamyl transferase is upregulated after oxidative stress through the Ras signal transduction pathway in rat colon carcinoma cells. Free radical research, 41(12), 1376-1384.

Gopal, N., Selvam, A., Srinivasan, A. R., Saha, S., and Muddegowda, P. H. (2012). Serum Gamma GlutamylTransferase levels in Obese South Indian adults with reference to atherogenic lipid risk factors and lipid peroxides. Int J Med Health Sci, 1(2), 35-42

Journal of University of Anbar for Pure Science

Effect of age on some renal function tests, uric acid, and gamma glutamyl transferase (GGT) in sample of Iraqi men over 40 years

References

References

Volume 12, Issue 1
April 2018
Page 75-82

Effect of age on some renal function tests, uric acid, and gamma glutamyl transferase (GGT) in sample of Iraqi men over 40 years

References

References

Volume 12, Issue 1April 2018Page 75-82

Volume 12, Issue 1
April 2018
Page 75-82