Like other soluble lead compounds, exposure to lead chloride may cause lead poisoning, In the current study, we seek to determine the effect of lead chloride on body and liver weight, as well as histological changes of the liver, in addition to the possibility of reducing the toxic effects of lead chloride by using natural products like garlic. Twenty-five healthy mice were divided into five groups: the first group was kept as an unmedicated control, while the second and third groups were given Lead chloride at a dose of 8.3 and 4.2 mg/kg, respectively; the four groups were given only garlic at a dose of 200 mg/kg; and the five groups were given lead chloride (8.3mg/kg) plus garlic in the same previous dose. This study's results show no significant difference in liver and body weight between groups except in the group that received a high dose of lead chloride. And for the histological changes in the liver, this study showed focal granulomatous, congestion, necrosis space, hepatocyte degeneration, and inflammatory cells were also observed, especially in groups that received high doses of Pbcl2. The present study proved that heavy metals containing lead have toxicological effects on the liver, so this effect can be decreased by natural products like garlic, which has a large activity in removing toxins like this.