Document Type : Review Paper


Department of Chemistry, College of Science, University of Anbar, Ramadi, Iraq;


in this paper show Mix ligand composed of (HL1) Dimidone and (HL2) 1,2-dibenzothiophene were allowed to react with next metal ions: Cobalt (III), Manganese (II), iron (III), Cobalt (II), Nickle (II), Cupper (II), Zinc (II) and Cadmium (II) individually forming stable metal complexes with different geometries as indicated using various techniques. The formation of the complexes as well as the geometries of the complexes were detected by Fourier-transform-infrared, mass_spectra, elemental analysis and electronic spectra. Moreover, the solubility of the compounds was tested in various solvents including: CHCl3, THF, DMF, DMSO, C2H5OH and H2O. Furthermore, the vital effectiveness was tested toward two types of bacteria gram negative bacteria (Spuedomonas & Escherichia coli was abbreviate (E. Coli) and positive bacteria ( Staphylococcus aureus was abbreviate Staph. Aureas & Bacillus) and two types another of fungi (Aspergillus niger & Fuzaium) giving different inhibition values (either effective or noneffective) as detailed in the manuscript.


Main Subjects

  1. Chen, M., Guo, Z., Lanier, M. C., Zhao, L., Betz, S. F., Huang, C.Q., Loweth, C.J., Ashweek, N.J.,& Liu, X.J. (2007). Identification of 2-(4, 5, 6, 7-tetrahydro-1H-pyrrolo [3, 2-c] pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists. Bioorganic & medicinal chemistry letters, 17(14), 3845-50. DOI: 10.1016/j.bmcl.2007.05.009.
  2. 2. El-Sherif, A.A., & Eldebss, T.M. (2011). Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu (II), Ni (II), Mn (II), Co (II) and Zn (II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 79(5),1803-14. DOI: 10.1016/j.saa.2011.05.062.
  3. El-Dissouky, A., Shuaib, N.M., Al-Awadi, N.A., Abbas, A.B., El-Sherif, A. (2008) Synthesis, characterization, potentiometric and thermodynamic studies of transition metal complexes with 1-benzotriazol-1-yl-1-[(p-methoxyphenyl) hydrazono] propan-2-one. Journal of Coordination Chemistry, 61(4),579-94. DOI:10.1080/00958970701365492.
  4. Buldurun, K. (2020). Synthesis, characterization, thermal study and optical property evaluation of Co (II), Pd (II) complexes containing Schiff bases of thiophene-3-carboxylate ligand. J. Electron. Mater, 4(3),1935-43.
  5. Mayans, J., Gómez, D., Font-Bardia, M., & Escuer, A. (2020) Chiral Oxazolidine Complexes Derived from Phenolic Schiff Bases. Crystal Growth & Design, 20(6), 4176-84.
  6. Mohamed, G.G., El-Sherif, A.A., Saad, M.A., El-Sawy, S.E., & Morgan, S.M. (2016) Mixed-ligand complex formation of tenoxicam drug with some transition metal ions in presence of valine: Synthesis, characterization, molecular docking, potentiometric and evaluation of the humeral immune response of calves. J. Mol. Liq, 22(3)1311-32. DOI:10.1016/j.molliq.2016.09.065.
  7. Jiang, Y., Dey, S., Ke, H., Yang, Y., Sun, L., Xie, G., Chen, S., & Rajaraman, G. (2023). Steric hindrance effect of Schiff-base ligands on magnetic relaxation dynamics and emissive behavior of two dinuclear dysprosium complexes. J. Rare Earths, 41(7),1049-57. DOI:10.1016/j.jre.2022.04.019.
  8. El-Sonbati, A. Z., Diab, M. A., Morgan. S. M., Abou-Dobara, M. I., & El-Ghettany, A. A. (2020). Synthesis, characterization, theoretical and molecular docking studies of mixed-ligand complexes of Cu (II), Ni (II), Co (II), Mn (II), Cr (III), UO2 (II) and Cd (II). J. Mol. Struct, 15(1200), 127065. DOI:10.1016/j.molstruc.2019.127065.
  9. Reda SM, Al-Hamdani AA. Mn (II), Fe (III), Co (II) and Rh (III) complexes with azo ligand: Synthesis, characterization, thermal analysis and bioactivity. Baghdad Science Journal. 2022.
  10. Al Zoubi, W., Jirjees, V., Suleman, V., Al‐Hamdani, A. A., Ahmed, S. D., Kim, Y. G., & Ko, Y. G. (2019). Synthesis and bioactivity studies of novel Schiff bases and their complexes. J. Phys. Org. Chem, 32(11), e4004.
  11. Al Zoubi, W., Kim, M. J., Salih, Al‐Hamdani A. A., Kim, Y. G., & Ko ,Y. G. (2019). Phosphorus‐based Schiff bases and their complexes as nontoxic antioxidants: Structure–activity relationship and mechanism of action. Appl. Organomet. Chem, 33(11), e5210. DOI:10.1002/aoc.5210.
  12. Kareem, M. J., Al-Hamdani, A. A., Ko, Y. G., Al Zoubi, W., & Mohammed, S.G. (2021). Synthesis, characterization, and determination antioxidant activities for new Schiff base complexes derived from 2-(1H-indol-3-yl)-ethylamine and metal ion complexes. J. Mol. Struct, 5(1231), 129-669. DOI:
  13. Obaid, S. M., Sultan, J. S., & Al-Hamdani, A. A. (2020). Synthesis, Characterization and Biological Efficacies from Some New Dinuclear Metal Complexes for Base 3-(3, 4-Dihydroxy-phenyl)-2-[(2-hydroxy-3-methylperoxy-benzylidene)-amino]-2-methyl Propionic Acid. Indones. J. Chem, 20(6), 1311-22.
  14. Al-Qudsi, Z. N., & Abood, H. M. (2013) The Electronic Transition Behavior Cr (III), Fe (III), Fe (II) and Ni (II), Transition Metal Cations In Ammonium Alum-Urea Room Temperature Ionic Liquid. ANJS. 16(3),46-55. DOI: 10.22401/JNUS.16.3.06.
  15. Patange, V. N., Pardeshi, R. K., & Arbad, B. R. (2008). Transition metal complexes with oxygen donor ligands: a synthesis, spectral, thermal and antimicrobial study. J. Serb. Chem. Soc, 73(11),1073-82. DOI:10.2298/JSC0811073P.
  16. Al Zoubi, W., Al‐Hamdani, A. A., Ahmed, S.D., & Ko, Y. G. (2018). A new azo‐Schiff base: Synthesis, characterization, biological activity and theoretical studies of its complexes. Appl. Organomet. Chem., 32(1), e3895. ZOUBI ET AL.15 of 15.