Document Type : Research Paper
Authors
University of Baghdad - College of Science
Abstract
A series of new phthalimides and succinimides connected to 1,3,4-oxadiazole moiety
were synthesized via multistep synthesis. The first step involved synthesis of six 5- substituted 2-
amino-1,3,4-oxadiazoles by oxidative cyclization of substituted semicarbazones under treatment
with bromine and anhydrous sodium acetate in glacial acetic acid.The synthesized 2-amino-1,3,4-
oxadiazoles were introduced in reaction with phthalic or succinic anhydride in the second step
producing six N - ( 5- substituted-1,3,4-oxadiazole-2-yl) phthalamic acids and six N-(5-substituted
-1,3,4-oxadiazole-2-yl) succinamic acids which in turn were dehydrated in the third step via fusion
method or using acetic anhydride and anhydrous sodium acetate as dehydrating agent to afford
the desirable N-(5-substituted -1,3,4-oxadiazole -2-yl) phthalimides and N-(5- substituted -1,3,4-
oxadiazole -2-yl) succinimides respectively.Structures of the prepared compounds were confirmed by
spectroscopic analysis and C.H.N analysis.Some of the synthesized compounds were screened for
their antibacterial activity against two microorganisms, staphylococcus aureous (Gram positive) and
Escherichia coli (Gram negative) and the results indicated that they exhibit good to moderate
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