Document Type : Research Paper
Authors
Samarra University - College of Education
Abstract
Cross-sectional study was carried out at 105 specimen of serum divided to (70) specimen for patients with type II diabetes mellitus (40) male and (30) female, and (35) specimen for healthy (18) male and (17) female individuals in order to study the effect of disease to the liver functions.The results showed that significantly elevated the activity of Enzymes, total protein and uric acid in sera of patients with type II diabetes mellitus as compared with healthy Individuals as control group.
The effect of hypertension was also studies to the levels of liver function parameters of patients with diabetes mellitus. The results showed increased in the levels of GOT, GPT and decreased in the levels of GGT in sera of patients with hypertension and D.M. as compared with the patient of D.M. only, while the levels of albumin, total protein and uric acid were slightly elevated in sera of patients with hypertension and D.M. as compared with patient with D.M. only.
Main Subjects
- لنیجر، ألبرت- ترجمة: الجلبی، قصی عبد القادر .الوجیز فی الکیمیاء الحیاتیة. مطبعة جامعة الموصل، 1986.
- Limaye, P.V. Raghuram, N and sivakami, S. Oxidative stress and gene expression of enzymes in the renal cortex of streptozoto induced diabetic rats. Molecular and cellular Biochemistry 243:2003; 147-152.
- King, M.W. Medical Biochemistry. Academic Excelience, 2004; 171-175.
- Anderson, J. R. Muir’s Text book of Pathology. Edward Arnold (Publishers) Ltd, 1980; 1030.
- Rorsman, P. Review: Insulin secretion: function and therapy of pancreatic beta-cells in diabetes. British Journal of Diabetes & Vascular Disease. Vol. 5, No. 4, July 2005; 187-191.
- Uma, K. and Michael, W. Clycohemoglobin: A primary predictor of the development or reversal of complications of diabetes mellitus. Clinical Chemistry. 47: 2001; 1157-1165.
- خاشع الروای، مدخل إلى الإحصاء، مطبعة جامعة الموصل، 1982.
- Farswan, M., Papiya Mitra Mazumder, V. Percha. Protective effect of Cassia glauca Linn. on the serum glucose and hepatic enzymes level in streptozotocin induced NIDDM in rats. Indian J. Pharmacol. Vol 41, Issue 1, Feb 2009; 19-22.
- Moller D. New drug targets for type 2 diabetes and the metabolic syndrome: A review. Nature. 414, 2001; 821-7
- مهدی، نجلاء صالح مهدی. دراسة بعض المعاییر الکیمو حیویة لمرضى داء السکری الوافدین الى مستشفى الحکیم فی محافظة النجف الاشرف. مجلة جامعة الکوفة لعلوم الحیاة. مجلد (1) العدد (2) لسنة 2009. ص 1-6.
11. Bolkent,S. , Özlem Saçan2, Ayşe Karatuğ1, Refiye Yanardağ. The Effects of Vitamin B6 on the Liver of Diabetic Rats: A Morphological and Biochemical Study. IUFS Journal of Biology. IUFS J Biol. 67(1): 2008;1-7
12. Angulo, P and Lindor, K.D. Kuadrennial Review Non-alcoholic fatty liver disease. Journal of Gastroenterology and Hepatology. 17 (Suppl.): 2002; S186–S190.
13. Inaba, M., Nagasu, K., Okino, S., Ueda, M. . Impaired secretion of parathyroid hormone in hemodialyzed patients with diabetes mellitus. Am. J. Kidney Dis., 39: 2002; 1269-1272.
14. Anon, GL. Becalmed. A review Drugs. 1:1971; 116 -140 (plumbed 5004340).
15. Hoechst -Roussel. Pharmaceuticals incdiabetes (glybride) prescribing information somer ville, Nj. 1987.
16. Toth , Peter P. Mosbys Drug Consult. 2002;1310-1317.
17. Giboney, Paul T. Mildy. Elevated liver transaminase levels in the asymptomatic patient . Journals American Family Physician. 71(6): 2005.
18. Bennett, P.N., and brown, M.J. Clinical Pharmacology. 9th ed, 2003; 653-658.
19. Martin, David W., Mayes, Peter A., Robwell, Victor &Associate Authors. Harpers Review of Biochemistry 18th ed, Middle East Edition, 1981; 61.
20. Dufour, D; Lott, J. and Henry, Knoth, E. Clinical Enzymology in Clinical Diagnosis of Management by Laboratory Method. 20th ed. 2001; 281.
21. Haigh,T., Chen,C., Jones, C. et al. Studies of mesechymal Cells from 1st. Trimester human placenta. Expression of Cyto keratin out side the trophoblast lineage. Placenta 20: 1999; 615-625.
22. Mansour, H.A., Newairy, A.A, Yousef, M.I. and sheweita, S.A. Biochemical study on the effects of some Egyptian herbsin alloxan-induced diabetic rats. Toxicology. 170(3): 2002; 221-228.
23. Barneo, L., Esteban, M.M., Garcia, C., Diaz, F. and Martin, B. Normalization of altered liver function tests after islet transplantation in diabetic rats. Diabetes. 38:1989; 320.
24. Itoh, S., Tsukada, Y., Motomura, Y. and Ichinoe, A. Five patients with non alcholic diabetic cirrhosis. Acta. Hepta. Gastroenterol. 26: 1979; 90-97.
25. Belfiore, F., Lo recchio, L. and Napoli, E. Serum enzymes in diabetes mellitus. Clin. Chem. 19(5): 1973; 447-452.
26. Martin, D. W, Mayes, P. A, Rodwell, V. W. and Granner, D K. Harper’s Review of Biochemistry, 20th ed., lange. Medical Publication/Los Altos, California, 1985; 258.
- العمری، محمد رمزی. الکیمیاء السریریة العملی، دار التقنی للطباعة والنشر، مؤسسة المعاهد الفنیة ، 1986،ص101.
28. Genuth, S., Lipps, J., Lorenzi, G., Nathan, D.M. Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. J. American Medical Association, 287(19): 2002; 2563-2569.
29. Mehta, K.N., Parik K.H., Chag, M.C., Shah, V.G. Effect of treatment on homocysteine mia in cardiac patients; a prospective study. Indian J. of Pharma. 45(5): 2003; 410.
30. Sezer, S., Ozdemir, F.N., Akman, B., Arat, Z, Anaforoglu, I. and Haberal, M. Predictors of serum albumin level in patients receiving countinuous ambulatory peritoneal dialysis. Adv-perit. Dial. 17: 2001; 210-214.
31. Mongensen, C.E., Keane, W.F., Beneth, P.H., Jerums, G., Parving, H.H. and Passa, P. Prevention of diabetic renal disease with special reference to microalbuminuria and macroalbuminuria. Lancet. 346:1995; 1080-1084.
32. Mongensen, C.E. How to Protect the Kidney in Diabetic Patient. Diabetes. 46(2): 1997; 324-332.
33. Pylypchuk, G., Beaubien, E. Diabetic nephropathy. Prevention and early referral. Can. Fam. Physician. 46: 2000; 636-642.
34. Rodionov, R.N. Urateas an endogenous antioxidant. The University of Iowa, Iowa city, IA 52242. 2003.
35. Marra, G., Cotroneo, P., Pitocco, D., Manto, A. Di-Leo, M.A., Ruotolo, V. Caputo, S. Glardina chirlanda, G. Santini, S.A. Early increase of oxidative stress and reduced antioxidant detenses in patients with uncomplicated type diabetes: a case of for gender difference. 25(5): 2002; 370-375.
36. Rocchini, A.P. Insulin resistance, obesity and hypertension. J. Nutr. (Suppl.6) 125: 1995; 1718S-1724S.
37. Drury, P.L. Diabetes and arterial hypertension. Diabetologia. 24: 1, 1983.
38. Nasri, H. Association of serum lipoprotein (a) with hypertension in diabetic patients. Saudi J. Kidney Dis. Transpl., 19(3): 2008; 420-427.
39. Dodson, P.M. and Horton, R.C. The hypertension of diabetes mellitus mechanism and implication. J. Hum. Hyperten. 1: 1988; 241.
)
