Print ISSN: 1991-8941

Online ISSN: 2706-6703

Volume 16, Issue 1

Volume 16, Issue 1, Summer and Autumn 2022, Page 1-81

Evaluation The Role of CD33+ CD11b+ myeloid-derived Suppressor Cells in Patients With AML

Hala mahdi Hamad; Zeyad Ahmed Shabeeb; Muthanna M. Awad

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 1-8
DOI: 10.37652/juaps.2022.174817

Acute myeloid leukemia is a genetically heterogeneous clonal disease defined by the accumulation of immature cells in bone marrow and blood. The aim of this study is to evaluate the CD33, CD11b, and HLA-DR expression in Iraqi AML patients and its role in evasion of malignant cells from the immune system. This study was conducted on 60 patients with AML and 20 healthy individuals as a control group to evaluate the expression of CD33 and CD11b using flow-cytometry in peripheral blood, and evaluate Interferons-γ (IFN-γ) and Transforming Growth Factor-β1 (TGF-β1) levels. A statistically non-significant difference (P < 0.005) between the AML patients and control group with regard to the expression of CD33, CD11b, and HLA-DR was observed. Analysis of CD33 expression in myeloid-derived suppressor cells (MDSCs) showed a significant decrease in the proportion of CD33 positive MDSC cells in isolated peripheral blood samples (88.078 ± 1.284). Also, the expression of CD11b in MDSC cells was high (98.841±1.935) in MDSC cells. The mean level of IFN-γ (pg/ml) increased in AML in compared to control group (9.202 ± 0.244), (7.906±1.22), respectively. While TGF- β1 (pg/ml) concentration was found to be elevated in AML patients (69.04 ± 9.92) compared to control group (33.884 ± 2.888). In conclusion, circulating MDSCs were significantly elevated in peripheral blood of patients with AML and characterized by the CD33+CD11b + phenotype; TGF-β1 and IFN-γ can be released in the presence of native human AML cells and affect AML cell proliferation and evasion from immune system.

Correlation of Chronic Viral hepatitis B and liver function Tests

Rana Mohsen; Estabraq gayadh; Raghad H. Al-azzawi; Ali Adhiah

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 9-12
DOI: 10.37652/juaps.2022.174819

Hepatitis B virus (HBV) infection is one of the important challenges facing the world. The persistence or clearance of HBV is often determined by the host's immune responses. The current study was conducted during June-October 2018 on 80 patients with chronic HBV infection and 96 age- and gender-matched healthy controls. The results showed that most of the patients were males (62.5%) while females constituted 37.5%. The patients' serum was positive for anti-HBc IgG and HbsAG antibodies, while it was negative for anti-Hbc IgM antibodies. These findings were consistent with the interpretation of chronic HBV infection. Four liver function tests were performed, including alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total serum bilirubin (TSB). A significant increase in ALP, ALT, and AST levels was observed in HBV patients compared to healthy controls, while TSB showed no significant differences. However, in the receiver operating characteristic curve analysis, only ALP and AST occupied an excellent area under the curve, which was > 0.90.

Nucleosides Bearing Quinazoline Moiety and Evaluation Their Antimicrobial effects

Mohammed Abed Kadhim; Maher EL-Hashash; Samh Rizk

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 13-19
DOI: 10.37652/juaps.2022.174831

The present work describes convenient synthesis of the novel Schiff bases 4, 5 and 6 by reaction of each of the previously synthesized quinazolinones 1, 2 and 3 with p-methoxybenzaldehyde. [2+2] Cycloaddition Reaction of the former Schiff bases within phenylisothiocyanate affording azatedine derivatives 7 and 8. Also, the quinazolines 1 and 2 could be reacted with α-bromoglucose tetraacetate giving peracetylated N-glycosides of quinazolinones 9 and 10 which were then deacetylated to afford N-glycosylated quinazolinones 11 and 12 respectively. On the other hand, Dapsone was reacted with p-methoxyacetophenone to afford 4-[(4-aminophenyl) sulfonyl]-N-[(1E)-1-(4-methoxyphenyl)ethylidene]aniline 15 which was, in turn, reacted with 4-chloro-2-ethoxyquinazoline 16 affording Schiff base 17. The latter was reacted with 2-furoyl chloride affording Schiff base 18. The structures of the novel Schiff bases and N-glycosides were confirmed by the IR, 1H-NMR, 13C-NMR, MS and elemental analysis. The antimicrobial activity for these synthesized compounds could outline, the moderate activity was observed  with new quinazoline compounds which proved to possess marked activity against E. coli, S. aureus and C. albicans. The strong activity has observed nearly with the most synthesized compounds .

A Short Review: Chemistry of Curcumin and Its Metal Complex Derivatives

Taghreed Al-Noor; Ali Ali; Ali Al-Sarray; Omar Al-Obaidi; Abeer Obeidat; Reem Habash

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 20-26
DOI: 10.37652/juaps.2022.174832

This review covers recent progress in the synthesis of curcumin and the bioactivity of semisynthetic and synthetic analogs of curcumin. The review also shows how curcumin is a useful intermediate for the synthesis of more complex organic molecules; historical perspective; the process of preparing the metal complexes and characterization the produced complexes using various spectral and other techniques; shows the importance of curcumin and its derivatives for their potential applications in medical devices and broad-spectrum of medical application such as antibiotic ointment, alternative therapeutics, antifungal, and antibacterial activities.

A Relationship of Periostin with some Bio- parameters in Type2 Diabetic Patients without and with COVID19

Samah Alkubaisi; shakir Alaaraji

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 27-32
DOI: 10.37652/juaps.2022.174833

Background: Type 2diabetes mellitus (T2DM) is a prolonged disease characterized by hyperglycemia resultant from weakening in insulin secretion, insulin action or both. T2DM and its associated metabolic disorders have been stated as the main cause in coronavirus disease 2019 (COVID-19). Current study was designed to investigate the association of periostin with some parameters in T2DM patients without and with COVID19.
    Materials and methods: This study involved of 56 patients, 28 with T2DM without any complications, the other 28 have T2DM with COVID19 attending Al-Fallujah teaching hospital, and 28 healthy persons matching in age, gender and ethnic background as control group. Serum level of periostin was estimated by ELISA technique while urea and creatinine were assessed by colorimetric enzymatic methods. Total protein and albumin were determined by biuret method.
    Results: Serum level of periostin was elevated in the T2DM patients without and with COVID19 than in healthy controls (HCs). The levels of urea and creatinine were importantly higher in T2DM patients without and with COVID 19 than in HCs (P < 0.000l), while total protein and albumin were lower in T2DM patients without and with COVID 19 than in HCs (P < 0.000l). Periostin had significant positive association with fasting serum glucose (FSG), HbA1c, urea creatinine, BMI, and ALB/GLB (P     Conclusion: Serum level of periostin may be used as a novel biomarker in diagnosis T2DM without and with COVID19.

Investigation Of Electrical And Magnatical Multiples Contributions To The Total Longitudinal And Transvers Firm Factors In Some Positive 25mg States Using Different Interactions

Nabeel Lattoofi; Samaher Mashaan

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 33-41
DOI: 10.37652/juaps.2022.174834

The nuclear structure of the 25Mg nucleus was studied using the shell model and Skyrme computations. For positive parity low (energy states, inelastic electron scattering form factors, energy levels, charge density distribution, and transition probabilities) have all been determined. The SKX parameters were used with the sd shell model. The best results were obtained from HBUMSD, HBUSD, CWH, PW, and W interactions, which were calculated on sd space interactions. For positive parity states, the excitation energies and transition probabilities to the ground state 5/2+ have also been determined. The experimental data was compared to the estimated form factors, energy level diagrams, and transition probabilities. The Skyrme interaction was shown to be compatible with a shell model is used to explore nuclear structure.

Investigation of electrical and magnetical multipoles contributions to the total longitudinal and transverse form factors in some positive and negative 27Al states using different interactions

Nabeel Lattoofi; Samaher Mashaan

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 42-49
DOI: 10.37652/juaps.2022.174836

The shell model and Skyrme interaction calculations were used to study the nuclear structure of the 27Al nucleus. In particular, inelastic electron scattering form factors, energy levels, and transition probabilities for positive and some negative parity low energy states have been calculated. The sd shell model was used with SKX parameters for positive parity cases. The calculations were performed on sd space interactions and the best results were obtained from HBUMSD, HBUSD, CWH, PW, and W interactions. For negative parity cases, the zbm model space with SKXcsb parameters has been used with zwm interactions. The excitation energies and transitions probabilities to the ground state 5/2+ for positive parity states have been also calculated. The calculated form factors, energy level diagrams, and transition probabilities were compared with the available experimental data. It was confirmed that the Skyrme interaction is suitable with the shell model to study the nuclear structure.

Improved sensing properties of Zinc Oxide gas sensor to detect hydrogen gas by using ZIF-8

Ausama Khudiar

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 50-54
DOI: 10.37652/juaps.2022.174837

In this research, ZnO nanorods were utilized as gas sensor materials for detecting toluene vapour and hydrogen gas prior to and following the use of Zeolitic imidazolate frameworks-8 (ZIF-8) as gas filter. On porous Al2O3, ZIF-8 was deposited and the thickness was 200 nm. Scanning electron microscope (SEM), XRD, and gas sensing tests were used to examine the material characteristics regarding ZIF-8 and ZnO. Thin films' sensitivity and selectivity to different gases such as C7H8 and H2 were also investigated. Comparing with pristine ZnO nanorods sensor, ZnO sensor is highly sensitive to C7H8 and H2, whereas the nanostructure regarding ZnO with ZIF8 as sensor has significantly selective response to the hydrogen gas. The small pore aperture of the ZIF-8 explains this behavior as H2 molecules could rapidly spread across ZIF-8 network and reach the surface of the ZnO.

Negative Doublet Bands with Different Shape in the 107Ag Nucleus

Nabeel Fawaz

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 55-58
DOI: 10.37652/juaps.2022.174838

The existence of chirality in the negative high spin states in the  107Ag nucleus has been confirmed by the Interacting Boson-Fermion Model (IBFM). IBFM excited states and electromagnetic properties are in good agreement with the available experimental data. According to IBFM analysis, the negative parity doublet bands (3) and ( 4) in the 107Ag nucleus were interpreted as triaxial and axial shap respectively.

Radiation Damage in the Structure of the CR-39 Nuclear Detector Material as A Result of the Alpha's Energy Loss

Khalid Flaih

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 59-64
DOI: 10.37652/juaps.2022.174840

In this work, the damage caused by the passage of alpha particles inside the CR-39 nuclear detector material on its chemical structure was studied. All samples at room temperature using a 241Am-Be neutron source with a flux of 5^10  were neutron-irradiated. In the CR-39 nuclear track detectors, chemical etching is a critical step in expanding latent tracks. At 70 °C, a NaOH in 6.25N etchant was found to be useful in expanding alpha traces in the CR-39 detector. The track depths of the Alpha particle as a function of etching time for the various energies were increased as etching time increases. The current study uses the nuclear track detector technique to estimate the range of alpha particles. Track etch rates are frequently determined using 2-dimensional photographs of track openings (diameter) or etching time data. The chemical structure along latent tracks and the track formation process were investigated in PADC(poly allyl diglycol carbonate). The findings showed that the measurement of bulk etch rate values by the weight method was 1.42 ± 0.02 μm/h. In addition, the results for the alpha particle range from 4.47 ± 0.05 and 5.8 ± 0.19 μm for alpha energy1.2 MeV and1.47MeV,respectively

Piecewise Monotone Approximation of Unbounded Functions In Weighted Space LP,w([-,])

Alaa Adnan; Sultan Mehiady

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 65-68
DOI: 10.37652/juaps.2022.174841

In this paper, investigate the approximation of unbounded functions in weighted space, by using trigonometric polynomials considered. We introduced type of polynomials piecewise monotone  having same local monotonicity as unbounded functions without affecting the order of huge error have a finite number of max. and min. unbounded functions that amount. In addition, we established not included any of extreme points of this functions,  of and closed subset γ on closed intervals  then there exist class of polynomials such that the best of approximation has high or order of and such that for  sufficiently great of the polynomials and functions have the same monotonicity at each of γ.

N- Monotone Approximation in Weighted Space

Alaa Adnan; Wameeth Mohammed Ali

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 69-74
DOI: 10.37652/juaps.2022.174842

The purpose of this paper is to discuss the degree of best monotone multi- approximation of unbounded functions weighted space in terms the modules of smoothness by using some algebraic linear operators. In addition, introduced ,proofs some properties of the modulus of smoothness.

Application of GIS Technique to Assess the Habbaniya Lake Water for Human Consumption

Mahmood Al-Kubaisi; Qusai Al-Kubaisi; Younus Al-Saady; Mufid alhadithi; Ammar Jasim

Journal of University of Anbar for Pure Science, 2022, Volume 16, Issue 1, Pages 75-81
DOI: 10.37652/juaps.2022.174843

Geographic Information System (GIS) technique was used in this study to produce a Water Quality Index (WQI) map to assess the water of Habbaniya Lake for drinking purposes. Sixteen samples of fresh surface water were collected and analyzed to verify the physiochemical parameters of the WQI. These parameters include Total Dissolved Solids, pH, Calcium, Magnesium, Sodium, Potassium, Chloride, Sulfate, and Nitrates. The result of these parameters has been transferred to the GIS platform to construct a water quality database and map of spatial distribution for each parameter using the inverse distance weight (IDW technique). The results of these parameters were also used to calculate irrigation water quality index values, and transferred to the GIS platform for the production of the water quality index map. The spatial distribution index of drinking water in Habbaniya Lake is depicted on this map. It shows that WQI for all water samples is within the second category (50-100) except (S 5 and S 8) below the second category (<50). The short-scope of WQI indicates that the water quality of Habbaniya Lake has been considered as convergent water quality that fluctuated from excellent water to good water for human drinking. It shows also that the northwestern part of Habbaniya Lake waters is more appropriate for drinking since the Al-Warar Canal drains in this part, which takes its water mainly from the Euphrates River.