Coated Wire and Multiwalled Carbon Nanotube Composite Coated Wire Sensors for Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations.

M. Jihad, Riyadh; K. Al-Hitti, Ismael; J. Hayder, Adawiya

doi:10.37652/juaps.2014.123989

Document Type : Research Paper

Authors

¹ University of Anbar - Education College for Women

² University of Anbar - College of Science

³ University of Technology - Nanotechnology Center

https://doi.org/10.37652/juaps.2014.123989

Abstract

fabrication and performance characteristics of novel potentiometric sensors for the determination of chlorpromazine hydrochloride are described. The proposed sensors include a coated copper wire sensor and a multiwalled carbon nanotube (MWCNT) composite coated copper wire sensor. The sensors are based on the chlorpromazine-phosphotungstate ion associate as electroactive material. The developed sensors exhibited near nernstian slopes of 53.69 and 57.31 mV concentration decade-1 at 25 ◦C, in the concentration range 5.0 x 10-5 – 1.0 x 10-2 mol L-1 chlorpromazine hydrochloride with limits of detection of 4.8 x 10-5 and 4.9 x 10-5 mol L-1 chlorpromazine hydrochloride for coated copper wire sensor and a (MWCNT) composite coated copper wire sensor, respectively. The proposed sensors exhibited good selectivity for chlorpromazine with respect to a large number of inorganic cations, amino acid and sugars. The developed sensor was successfully applied for the potentiometric determination of chlorpromazine hydrochloride in the pharmaceutical preparations and human urine samples.

Keywords

Main Subjects

Chemistry

References

[1] British Pharmacopoeia, the Stationery Office, London, (2000).

[2] H. P. Rang, M. M. Dale, J. M. Ritter, R. J. Flower and G. Henderson, Rang and Dale’s Pharmacology, Elsevier Churchill Livingstone, (2012).

[3] E. H. Drummond, The complete Guide to Psychiatric Drugs, John Wiley & Sons Inc., (2006).

[4] K. Madej, M. Kala and M. Wozniakiewicz, “LC and Non-Aqueous CE Determination of Phenothiazines in Autopsy Samples ” Chromatographia, 62: 533-538, (2005).

[5] C. Sasaki, T. Shinozuka, C. Murakami and W. Irie, “Simultaneous determination of 5 psychotropic drugs of various types in an autopsy case of acute multiple drug poisoning “ Forensic Science International, 227: 90-94, (2013).

[6] B. M. Fonseca, I. E. Moreno, M. Barroso and S. Costa, “Determination of seven selected antipsychotic drugs in human plasma using microextraction in packed sorbent and gas chromatography--tandem mass spectrometry “ Analytical and Bioanalytical Chemistry, 405: 3953-3963, (2013).

[7] L. Cheng, Y. Zhang, J. Shen and C. Wu, “GC--MS Method for Simultaneous Determination of Four Sedative Hypnotic Residues in Swine Tissues ” Chromatographia, 71: 155-158, (2010).

[8] K. Mitrowska, A. Posyniak and J. Zmudzki, “Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry ” Analytica Chimica Acta, 637: 185-192, (2009).

[9] M. Rani, H. Abdul Ahad, R. sreenivasulu, K. K. Reddy and M. Kumar,” Cerimetric Determination of Chloropromazine in Bulk Drug Form and In Tablets” Journal of Pharmacy Research, 4: 735-, (2011).

[10] M. L. C. Passos, M. L. M. Savaiva and J. L. F. Lima,” Enzymatic oxidation in aqueous and micellar media based on horseradish peroxidase-hydrogen peroxide system using a SIA manifold “ Talanta, 77: 484-489, (2008).

[11] H. Yang, X. Li, F. Yang and J. Feng, “Electrochemiluminescence detection system for microchip capillary electrophoresis and its application to pharmaceutical analysis” Microchimica Acta, 175: 193-199, (2011).

[12] J. Li, F. Zhao and H. Ju, “Simultaneous determination of psychotropic drugs in human urine by capillary electrophoresis with electrochemiluminescence detection “ Analytica Chimica Acta, 575: 57-61, (2006).

[13] F. J. Lara, A. M. Garcia, F. Ales and J. M. Bosque, “Development and validation of a capillary electrophoresis method for the determination of phenothiazines in human urine in the low nanogram per milliliter concentration range using field-amplified sample injection” Electrophoresis, 26: 2418-2429, (2005).

[14] K. Nesmerak, V. Cerveny, J. Hranicek and P. Rychlovsky, “A spectrofluorimetric determination of phenothiazine derivatives after their photooxidation or chemical or electrochemical oxidation in a flow injection arrangement “ Microchemical Journal, 106: 226-232, (2013).

[15] A. O. Joaguafan, G. Antonio and S. P. Concepciafan, “Flow-Injection Coulometric Detection Based on Ion Transfer and Its Application to the Determination of Chlorpromazine” Sensors, 8:3678-3688, (2008).

[16] Y. Li, W. Niu and J. Lu, “Sensitive determination of phenothiazines in pharmaceutical preparation and biological fluid by flow injection chemiluminescence method using luminol-KMnO4 system“ Talanta, 71: 1124-1129, (2007).

[17] W. Niu, N. Feng, F. Nie and J. Lu, “Investigating the post-chemiluminescence behavior of phenothiazine medications in the luminol--potassium ferricyanide system: molecular imprinting--post-chemiluminescence method for the determination of chlorpromazine hydrochloride “ Analytical and Bioanalytical Chemistry, 385: 153-160, (2006).

[18] G.J. Moody and J.D.R. Thomas, Selective Ion Sensitive Electrodes, Merrow Publication Co. Ltd, England 1971.

[19] R. P. Buck and E. Lindner, Pure & Applied Chemistry, 66: 2527-2532, (1994).

[20] F. Faridbod, M. R. Ganjali and E. N. Esfahani, “Potentiometric sensor for quantitative analysis of pioglitazone hydrochloride in tablets based on theoretical studies” International Journal of Electrochemical Science, 5: 880-894, (2010).

[21] P. Norouzi, H. Rashedi andA. Alipour, “PVC membrane sensor and wire coated electrode for determination of flurazepam” International Journal of Electrochemical Science, 6: 2312-2322, (2011).

[22] M. R. Ganjali, T. Razavi and F. Faridbod, “Application of a new tramadol potentiometric membrane sensor as useful device for tramadol hydrochloride analysis in pharmaceutical formulation and urine” Current Pharmaceutical Analysis, 5:28-33, (2009).

[23] I. M. Shakir and M. J. Hamzeh, “New approach development for determination of chlorpromazine HCl in pure and pharmaceutical forms using homemade wave length selector flow injection photometer” Kerbala Journal of Pharmaceutical Sciences, 3: 86-97, (2012).

Journal of University of Anbar for Pure Science

Coated Wire and Multiwalled Carbon Nanotube Composite Coated Wire Sensors for Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations.

References

References

Volume 8, Issue 3
December 2014
Page 20-27

Coated Wire and Multiwalled Carbon Nanotube Composite Coated Wire Sensors for Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations.

References

References

Volume 8, Issue 3December 2014Page 20-27

Volume 8, Issue 3
December 2014
Page 20-27