Relationship between arginase activity and renal function in sera of patients with the two types of diabetes mellitus

R. Hameed  I, Rafah; Sh. Ahmed, Gufran; F. Al-Auqb, Tawfeeq

doi:10.37652/juaps.2016.132703

Document Type : Research Paper

Authors

¹ University of Samarra - College of Education

² University of Al-Mustansiriya - National Center for Diabetes Treatment and Research

https://doi.org/10.37652/juaps.2016.132703

Abstract

Biochemical study was carried out to evaluate the activity of organs in sera of patients with two types of diabetes mellitus-DM ( 1 and 68 of type II ) as compared with healthy individuals as a control group. Biochemical parameters in the sera of groups which include: serum glucose,renal function-urea, creatinine and uric acid, the results indicate that the level of serum glucose,urea and creatinine significantly increased in the sera of patients with type I and II of diabetes militias as compared with a control group with no significant change in sera of patients with the two types of DM for uric acid as compared with the control group.The result showed significant change between control and patients with DM for serum arginase activity, and between the two types of DM, in which the mean±SD were (2.702±0.673)μmol/L/min in sera of type I of DM and (2.384±0.577) μmol/L/min for type II, the results indicate that the level of the enzyme significantly slightly higher in type I than type II. The correlation between the arginase activity and other biochemical parameters in patients with the two types of DM and control were studied, from the results we conclude that the activity of arginase was the effect by the disease (two types of DM), and the effect was slightly higher by type two of DM.

Main Subjects

Biology

References

1. McCarthy, M.I. and Zeggini, E. Genome-wide association studies in type 2 diabetes. Curr. Diab 2009 ;9(2):164-171.
2. King, M.W.Medical Biochemistry. Academic Excelience (2004); pp. 171-175.
3. Langer, P.; Kocan, A.; TajTakova, M. et al. Thyroid function and cholesterol level: paradoxical findings in large groups of population with high cholesterol food intake. Endocr.2010; 3:175-180.
4. Poretsky , LPrinciples of Diabetes mellitus .2nd edition.Springer. 2010; P. 886.
5. Hanas, R .Type 1 Diabetes in children, Aldolescents and young adults. 2nd Ed. Class publishing .London. 2004;P.394.
6. Petit,W.A. and Adamec ,C.; Encyclopedia of Diabetes 2nd Ed. Facts on file library of health and living. 2011;P.436.
7. Murray, R.K.; Granner, C.K.; Mayes, P.A.; and Rodwell , V.W.and Harpers' Biochemistry. 28th Ed ., Appleton and Lange, USA. 2009; Pp.155-156, 254-265, 332.
8. kumar, V. ; Fausto, N., Abbas, A.k.; Cotran, Ramzi, s; Robbins , Stanley LRobbins and cotranpathologic Basis of Disease ; 7thEd Philadelphia , Pa:Saunders, 2005; Pp.1194-1195.
9. Pannain.S. and Touma; C. Does lack of sleep cause diabetes .Cleveland Cli. J. med. 2011; 78 (8): 549-58 .
10. Poretsky,L. Principlesof Diabetes mellitus 2^nd edition.Springer. 2010; p:886.
11. Coulomble, J. J. and Favreau, L. A new simple semimicro method for colorimetric determination of urea. Clin. Chem., 1963:9-102.
12. Shen, K.; Ji Y, Chen, G.Q.; Huang, B.; Zhang ,X.; Expression and clinical significance of the NDA repair enzyme MYH in esophageal squamous cell carcinoma. Exp .Ther .Med 2011;2: 1117-1120.
13. Iyer, R.K: Arginases I and II: do their functions overlap? Mol Genet 2004;81 (1): 38-44,.
14. Murray, R. K.; Bender, D. A.; Botham, K. M.; Kennelly, P. J.et al . Harper's I llustrated biochemistry 29th Ed. MC. Graw Hill Lange, 2012;148-277.
15. Jenkinson, C. P.; Grody, W. W. and Cederbaum, S. D. Comparative properties of arginases. 1996.Comp Biochem Physiol B Biochem Mol Bio, l 114: 107-132.
16. Stephen, D. C.; Hong, Y.; Wayne, W.G.; Rita, M. K.; et al .. Arginase I and II: do their functions overlap?. Mol. Gen. Metab. 2004;81: 38-44.
17. Elgün, S.; Kacmaz, M.; Sen, I. and Durak, I. Seminal arginase activity in infertility. Springer.2000; 28: 20-23.
18. DiCostanzo, L.; Moulin, M.; Haertlein, M.; Meilleur, F. et al. Expression, purification, assay, and crystal structure of perpetuated human arginase I . archives of biochemistry and biophysics, 2007;465(1)
19. Cotran, R.; Kumar, V.; Robbin, S. and Schoen, F. Pathologic basis of disease. 5th Ed. W. B. Soundres Co. London. 1996; 930-986.
20. Haslett, C.; Chilvers, E. R.; Boone, N. A. and colledge, N. R. Davidson, s principles and practice of medicine.2002. 9th Ed.
21. Kashyap, S.R.; Lar, A.; Zhang, R.; Park, Y.M.; et al. Insulin reduces plasma arginase activity in type 2 diabetic patients. Diabetes care. 2008;31(1):134-9.
22. Abdilkarim Yehia J. AL-Sammraie , Al-Mustansiriyah ., Evaluation of Vitamin D Status in Patients with Type 1 Diabetes Mellitus . Journal of Science ,2015.Vol. 26, No 1.
23. Olli Helminen , Tytti Pokka , Pa ivi Tossavainen , Jorma Ilonen , Mikael Knip, Riitta Veijola . diabetes research and clinical practice 120 . 2016; 89: 96, Continuous glucose monitoring and HbA1c in the evaluation of glucose metabolism in children at high risk for type 1 diabetes mellitus
24. Nathan, D.M. International Expert Committee report on the role of the A1cassay in the diagnosis of diabetes . Diabetes care . 2009; 32: 1327–1334.
25. Layla O. Farhan , Determanation of Several Biochemical Parameters in Sera of Iraqi Patients with type 2 Diabetes . Bagh. Sci. J. 2015; 12(2).
26. Oday Jassim Al-salihy , The Effect of Impaired Fasting Glucose on Out Come of Patients with Acute Coronary Syndrome. Journal of Babylon University/Pure and Applied Sciences. 2016; 3 (24).
27. . Smith, A.F.; Beckett, G. J; Walker, S.W. and Rac, P.W. Clinical Biochemistry .1998; 6th ed, Blackwell Scienc..
28. . American Diabetes AssociationStandards of Medical Care in Diabetes. J. Diabetes Car.2013;35: 11- 66.
29. Mckenzie, J.M. and Zakarija, M. Hyperthyroidism. In: Endocrinology. Edited by DeGroot, L.J., 3rd ed., W.B. Saunders Company, Philadelphia, 1995; 1: 676-711.
30. Becker, B.F.; Towards the physiological function of uric acid. Free Rad. Biol. Med. 1993; 14: 615–631.
31. Strazzullo, P and Puig J.G. Uric acid and oxidative stress: relative impact on cardiovascular risk. Nutr. Metab .Cardiovasc Dis. 2007; 17: 409–414.
32. Becker, B.F.; Reinholz, N.; Leipert, B.; Raschke, P.; Permanetter Band Gerlach E. Role of uric acid as an endogenous radical scavenger and antioxidant. Chest. 1991; 100(l): 176–181.
33. Hayden, M.R and Tyagi SC. Uric acid: A new look at the old risk marker for cardiovascular, metabolic syndrome, and type 2 diabetes mellitus: The Urate redox shuttle. Nutr. Metab. 2004; 1: 10.
34. Tuomilehto, J.; Zimmit, P.; Wolf, E.; Taylor, R.; et al.. Plasma Uric Acid level and its association with diabetes mellitus and some biological parameters in biracial population of Fiji. Am .J .Epidemiol .1988; 127: 321–36.
35. Causevic, A.; Semiz, S.; Macic-Dzankovic, A.; Cico, B.; et al.. Relevance of Uric Acid in progression of type 2 diabetes mellitus. Bosnian Medical Science .2010; 10: 55–99.
36. Dehghan, A.; von Hoek, M.; Sijbrands, E.J.; Hofman, A and Witteman JC. High serum uric acid as a novel risk factor for type 2 diabetes mellitus. Diabetes Care .2008; 31: 361–362.
37. Ul Amine, N.; Mahmood, T. R.; Asad, M.J.; Zafar, M. et alElvaluating urea and creatinine levels in chronic renal failure pre and post dialysis a prospective study. 2014; l2(2).
38. function : new insight into old concepts. 1992 ; 38 ( 10).
39. Kikkawa, R.; Koya, D. and Haneda, MProgression of diabetic nephropathy. Am. J. Kidney Dis. 2003;41: 19-21.

Journal of University of Anbar for Pure Science

Relationship between arginase activity and renal function in sera of patients with the two types of diabetes mellitus

References

References

Volume 10, Issue 2
August 2016
Page 81-89

Relationship between arginase activity and renal function in sera of patients with the two types of diabetes mellitus

References

References

Volume 10, Issue 2August 2016Page 81-89

Volume 10, Issue 2
August 2016
Page 81-89