Document Type : Research Paper
Authors
Department of Chemistry - College of Education for women - University of Anbar
Abstract
In this research , the biological activity for some of new
prepared Acetlynic Amine complexes have been study through effect of these
complexes to used as activation and reactivation AChE enzyme inhibited by
organophosphorous compound which used in herbicide or chemical war in
blood serum.The inhibition of AChE by some organophosphorous compounds:
TEP=TriethoxyPhosphinoxide,
TDMAP=Tris(DiMethylAmine)Phosphenoxide
has been studied for the first time.
From the degree of inhibition obtained, the time of incubation and inhibitor
concentration for the highest inhibition have been determined.
The results obtained from (Linweaver –Burk) plot indicates that the inhibition is
Non-Competitive.The inhibition percentages obtained confirmed that TEP has a
higher inhibition than TDMAP. The fect of (zinc, cadmium and mercury) (II) of
acetlynic amine (N-Propargyl pipredine) complexes on the activity of the
inhibited enzyme has been studied.The resuls obtained from the incubation time
and concentration experiments of the above complexes with inhibited enzyme,
showed that all the complexes behave as re-activators
Main Subjects
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